AMORPHOUS SELENIUM IMAGING FOR TOMOTHERAPY

用于断层放射治疗的非晶硒成像

• 批准号: 2717570
• 负责人: GUANG M FANG
• 金额: $ 9.89万
• 依托单位: TOMOTHERAPY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-05 至 2001-03-04
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2717570
• 关键词: amorphous solid; biomedical equipment development; imaging /visualization /scanning; photoconduction; radiation detector; radiation dosage; radiation therapy; selenium; tomography

Tomotherapy has the potential to provide much better radiation therapy because it combines optimized radiotherapy treatment planning, intensity modulated radiation delivery and tomographic verification. TomoTherapy, Inc. is developing a commercial tomotherapy system, but we are missing a key enabling technology: a detector for optimized megavoltage computed tomography. This technology will allow more conformal dose distributions to be verifiably delivered. A key enabling technology for tomotherapy is megavoltage computed tomography. Existing computed tomography imaging systems do not have optimal performance for tomotherapy applications. This proposal explores the use of thin film amorphous selenium (a-Se) imaging for use in tomotherapy. Critical issues to be investigated in Phase I are feasibility, linearity, stability and temporal response of the system. A preliminary design for a prototype will be developed. In Phase II we will design the thin film arrays and readout electronics, fabricate a prototype detector and evaluate its performance for tomotherapy. This is the key enabling technology to allow tomotherapy to enter the marketplace. PROPOSED COMMERCIAL APPLICATIONS: Tomotherapy is a promising new method to verifiably deliver highly conformal dose distributions for cancer therapy. The total market for radiotherapy delivery equipment is hundreds of millions of dollars per year. One of the key technologies for enabling tomotherapy is a Computed Tomography-like megavoltage detector. Amorphous selenium imaging technology is highly promising for this application.

放射治疗有可能提供更好的放射治疗。 因为它结合了优化的放射治疗计划、强度 调制辐射传输和断层扫描验证。放射治疗， Inc.正在开发一种商业放射治疗系统，但我们还没有 一项关键的使能技术：一种用于优化兆伏计算的检测器 体层摄影术。这项技术将允许更多的共形剂量分布 以可核实的方式交付。放射治疗的关键使能技术 就是巨伏计算机断层扫描。现有的计算机断层扫描成像 对于断层治疗应用程序，系统没有最佳性能。 该提案探索了薄膜无定形硒(a-Se)的用途。 在放射治疗中使用的成像。要调查的关键问题 第一阶段为可行性、线性、稳定性和时间响应。 这个系统。将开发一个原型的初步设计。在……里面 第二阶段我们将设计薄膜阵列和读出电子设备， 研制了探测器样机，并对其性能进行了评估 放射治疗。这是使TomoTreatment能够 进入市场。 建议的商业应用： 放射治疗是一种很有前途的新方法，可以有效地提供 癌症治疗的保形剂量分布。中国的总市场 放射治疗输送设备每台数亿美元 年。实现断层治疗的关键技术之一是计算机 类似断层摄影术的巨伏探测器。非晶态硒成像 这项技术对这一应用非常有前景。