QUANTITATIVE EPITOPE MAPPING OF IGA TO HIV GP120
QUANTITATIVE EPITOPE MAPPING OF IGA TO HIV GP120
批准号:
2645271
负责人:
STEPHEN L CARRITHERS
金额:
$10.48万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1998
资助国家:
美国
项目状态:
已结题
起止时间:
1998-06-03 至 2000-06-30
中文摘要
尽管在…方面取得了重大进展
英文摘要
DESCRIPTION: Although significant progress has been made in the
development of an HIV-1 vaccine, we are just now beginning to make
progress toward the induction of mucosal immunity. A major limitation
on the development of mucosal vaccines has been difficulty in
quantitatively evaluating the immune response at mucosal surfaces. We
propose to develop an assay which will provide a quantitative measure
of epitope specific antibodies at the mucosa. It is our hypothesis that
the induction of mucosal antibodies can be accurately measured using
this method and that the information will lead to improved HIV-1
vaccines that will block the spread of infection. Our proposed
Quantitative Epitope Mapping ELISA format, or QEM ELISA, provides a
sensitive way of measuring the concentration of epitope specific
antibody. The assay can be easily adapted to analysis of samples with
widely varying levels of antibody including serum, saliva, feces, and
urine with minor modifications of the assay format. The assay can also
be used to measure isotype specific epitopes without the need to deplete
the sample for competing Ig subclasses or other interfering substances.
Long term the QEM ELISA will have broad application to the analysis of
vaccines for other disease (e.g. rotavirus, RSV, influenza, H. pylori,
HPV, etc.).
PROPOSED COMMERCIAL APPLICATION: Not available.
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海外基金