MORPHATIDETM SCAFFOLDING EVOLUTION LIBRARIES

说明(改编自申请)：在本建议书中 申请者寻求开发一种允许基因支架的新技术 有多种不同的化学成分。这些分子是指 作为变形剂。选择高纯度吗啡肽的可行性研究 将评估靶标(凝血酶和核糖核酸酶A)的亲和力。 将反复进行几轮耦合、选择和放大 用来提高构型的相互作用能力。如果 成功后，这种方法将大大简化和扩展能力 分离可用作探针试剂的小分子 分子途径，或作为临床成像、靶向或治疗 探员们。 建议的商业应用：不可用

DESCRIPTION (Adapted from the application): In this proposal the applicant seeks to develop a new technology to allow genetic scaffolding of multiple different chemical moieties. These molecules are referred to as morphatides. The feasibility of selecting morphatides with high affinity for the targets (thrombin and Rnase A) will be assessed. Reiterative rounds of coupling, selection and amplification will be utilized to improve the interactive ability of the morphatides. If successful, this approach will greatly simplify and expand the ability to isolate small molecules that can be utilized as reagents to probe molecular pathways, or as clinical imaging, targeting, or therapeutic agents. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE