PSEUDO-DXA BONE MINERAL DENSITY FROM 3DQCT EXAMS

描述：研究人员建议测试的可行性， 开发骨矿物质转换的算法和软件 从X射线计算机断层摄影到投影格式的测量数据 与双能X射线吸收测定装置相当，因为进一步 由他们的摘要描述： “QCT和DXA是临床上用于测量骨密度的方法 在中央骨架。 DXA被认为是首选方法 但是全世界的中心数量 做DXA不足以使这项技术普遍可用。 CT扫描仪的数量要多一个数量级。 “3DQCT通过消除重新定位误差提高了QCT的精度 在系列考试中。 采集体积数据集并将其传输到 PC进行分析。 临床上，3DQCT用于脊柱骨矿物质 骨密度（BMD）分析，而且在区域BMD的研究中 在股骨近端 CT分割骨骼的分割算法 来自软组织或来自组织的充满造影剂的血管， 所得到的数据被投影到2D图像中用于可视化。 我们将 将这些方法应用于3DQCT，构建骨密度的伪DXA图像 分析. 关键因素是准确测量骨密度的能力 在3DQCT数据集中逐个体素地进行。 “这项提案的长期目标是表明3DQCT可以 替代DXA，同时使用大量的 使用DXA开发的临床知识。 如果成功，这项工作可以 使DXA类BMD结果可用于任何具有CT扫描仪的站点。" 拟定商业应用： 未提供拟议的商业应用。

DESCRIPTION: The investigators propose to test the feasibility of developing algorithms and software for conversion of bone mineral measurement data from X-ray computed tomography to a projection format comparable to a dual-energy X-ray absorptiometry device, as further described by their abstract: "QCT and DXA are clinically used methods for measurement of bone density in the central skeleton. DXA is considered to be the method of choice by the internal medicine community, but the number of centers worldwide doing DXA is not sufficient to make this technique generally available. There is an order of magnitude larger number of CT scanners. "3DQCT improves the precision of QCT by eliminating repositioning errors in serial exams. A volumetric data set is acquired and transferred to a PC for analysis. Clinically, 3DQCT is used for spinal bone mineral density (BMD) analysis, but also in research studies for regional BMD in the proximal femur. Segmentation algorithms used in CT separate bone from soft tissue or contrast-filled vessels from tissue, and the resulting data are projected into a 2D image for visualization. We will apply these methods to 3DQCT to construct pseudo-DXA images for BMD analysis. The key factor is the ability to measure BMD accurately voxel-by-voxel in the 3DQCT data set. "The long-term objective of this proposal is to show that 3DQCT can substitute for DXA, while at the same time using the vast set of clinical knowledge developed using DXA. If successful, this work can make DXA-like BMD results available to any site with a CT scanner." PROPOSED COMMERCIAL APPLICATION: Proposed commercial application not available.