HIGH RESOLUTION OPHTHALMOSCOPE USING BESSEL BEAM

使用贝塞尔光束的高分辨率检眼镜

• 批准号: 2542655
• 负责人: TIN M AYE
• 金额: $ 10万
• 依托单位: PHYSICAL OPTICS CORPORATION
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-01-01 至 1998-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2542655
• 关键词: biomedical equipment development; charge coupled device camera; eye disorder diagnosis; eye fundus photography; eye movements; image enhancement; lasers; ophthalmoscopy; tomography

Partial coherence tomography (PCT) is a recently developed non-intrusive method of topographically profiling the optic nerve head, as well as tomographically measuring the nerve layer. This procedure can improve early diagnosis of glaucoma. Physical Optics Corporation proposes to enhance PCT by using a Bessel microbeam (BMB) probe beam to improve both the spatial resolution (by about 200 times over current PCT) and speed (by eliminating objective lens scanning in PCT). Based on preliminary results, the BMB is insensitive to eye movement, significantly improving the accuracy of retinal tomography. The proposed BMB technology can be applied to biomedical imaging and industrial inspection instruments. Because of its low cost and flexibility, its commercial potential is extremely high. In Phase I of this project, POC will investigate a number of Bessel beam phase shaping options and optimize the phase shaping design for ophthalmoscopes. High resolution and insensitivity to eye movement will be demonstrated. Proposed commercial applications: Compactness, low cost, and ease of integration with existing imaging systems make the proposed component broadly useful in high-resolution imaging. Commercial applications include direct writing lithography, microbeam semiconductor material processing, and medical imaging.

部分相干断层扫描（PCT）是最近发达的无侵入性的 地形分析视神经头的方法以及 在断层仪上测量神经层。此过程可以改善 青光眼的早期诊断。物理光学公司建议 通过使用Bessel Microbeam（BMB）探针束改善PCT 空间分辨率（超过当前PCT约200倍）和速度（通过 消除PCT中的客观镜头扫描）。基于初步结果 BMB对眼动不敏感，显着改善了 视网膜断层扫描的准确性。 提出的BMB技术可以应用于生物医学成像和 工业检查工具。由于其成本低和 灵活性，其商业潜力极高。 在该项目的第一阶段，POC将研究许多贝塞尔梁 相结合选项并优化相塑设计的设计 眼镜镜。高分辨率和对眼动的不敏感性将是 证明。 拟议的商业应用： 紧凑，低成本和与现有成像的易于集成 系统使所提出的组件在高分辨率上广泛有用 成像。商业应用包括直接写作光刻， Microbeam半导体材料处理和医学成像。