HIGH RESOLUTION OPHTHALMOSCOPE USING BESSEL BEAM

使用贝塞尔光束的高分辨率检眼镜

• 批准号: 2542655
• 负责人: TIN M AYE
• 金额: $ 10万
• 依托单位: PHYSICAL OPTICS CORPORATION
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-01-01 至 1998-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2542655
• 关键词: biomedical equipment development; charge coupled device camera; eye disorder diagnosis; eye fundus photography; eye movements; image enhancement; lasers; ophthalmoscopy; tomography

Partial coherence tomography (PCT) is a recently developed non-intrusive method of topographically profiling the optic nerve head, as well as tomographically measuring the nerve layer. This procedure can improve early diagnosis of glaucoma. Physical Optics Corporation proposes to enhance PCT by using a Bessel microbeam (BMB) probe beam to improve both the spatial resolution (by about 200 times over current PCT) and speed (by eliminating objective lens scanning in PCT). Based on preliminary results, the BMB is insensitive to eye movement, significantly improving the accuracy of retinal tomography. The proposed BMB technology can be applied to biomedical imaging and industrial inspection instruments. Because of its low cost and flexibility, its commercial potential is extremely high. In Phase I of this project, POC will investigate a number of Bessel beam phase shaping options and optimize the phase shaping design for ophthalmoscopes. High resolution and insensitivity to eye movement will be demonstrated. Proposed commercial applications: Compactness, low cost, and ease of integration with existing imaging systems make the proposed component broadly useful in high-resolution imaging. Commercial applications include direct writing lithography, microbeam semiconductor material processing, and medical imaging.

部分相干层析成像（PCT）是近年来发展起来的一种非侵入性成像技术， 视神经乳头的地形图分析方法，以及 断层扫描测量神经层。这个过程可以改善 青光眼的早期诊断Physical Optics Corporation建议， 通过使用贝塞尔微束（BMB）探测光束来提高PCT， 空间分辨率（比目前的PCT高出约200倍）和速度（ 消除PCT中的物镜透镜扫描）。根据初步结果， BMB对眼球运动不敏感，显著改善了 视网膜断层扫描的准确性。 所提出的BMB技术可以应用于生物医学成像， 工业检测仪器。由于其成本低， 灵活性，商业潜力极高。 在该项目的第一阶段，POC将研究一些贝塞尔光束 相位整形选项，并优化相位整形设计， 检眼镜高分辨率和对眼球运动的不敏感性将是 演示。 拟议的商业应用： 紧凑、低成本、易于与现有成像集成 系统使得所提出的组件在高分辨率 显像商业应用包括直写光刻， 微束半导体材料处理和医学成像。