NEURAL CORRELATES OF COCAINE ADDICTION TREATMENT

描述：(申请人摘要) 毒瘾康复可描述为三个主要阶段 治疗，每种治疗都有特定的目标，戒毒和戒断 缓解、减少吸毒和预防复发。在整个过程中 康复阶段必须解决吸毒成瘾的影响，并 以有效的方式管理。这可能是最关键的 预防复发阶段的治疗，这在许多方面是最好的 治疗结果成功的衡量标准。这项提案将调查 儿童条件性渴求反应与治疗结果的关系 可卡因依赖者。它将利用线索诱导的可卡因渴望 旨在评估可卡因的心理和神经基础的研究 渴求和相关线索诱导的状态，如唤醒、焦虑和 像可卡因一样的兴奋。这项研究的主要目的是测试 可卡因成瘾康复的积极结果与 对线索诱导的可卡因渴望的具体减少。 可卡因慢性影响的神经生物学关联一直是 以神经成像和定量脑电(QEEG)为基础的良好特征 学习。此外，心理生理学研究，如线索诱导 对可卡因的渴求提供了一种与可卡因成瘾有关的功能性措施。 通过将qEEG测量与线索诱导的可卡因渴求相结合，研究发现 提案将开发方法来检查脑出血的神经生物学基础 对可卡因上瘾的渴望。这项建议的次要目标是 线索诱发QEEG与心理生理学和认知功能关系的探讨 主观反应、成瘾严重程度和治疗结果。

DESCRIPTION: (Applicant's Abstract) Drug addiction rehabilitation can be described in three main phases of treatment, each with specific objectives, detoxification and withdrawal alleviation, reduction in drug use, and relapse prevention. Throughout each stage of rehabilitation the impact of drug craving must be addressed and managed in an effective manner. This is perhaps most critical during the relapse prevention phase of treatment, which in many regards is the best measure of treatment outcome success. This proposal will investigate the relationship between treatment outcome and conditioned craving responses in cocaine-dependent patients. It will employ cue-induced cocaine craving studies aimed at evaluating the psychological and neuronal basis of cocaine craving and related cue-induced states, such as arousal, anxiety and cocaine-like high. The primary aim of this study is to test whether positive outcomes in cocaine addiction rehabilitation are correlated with specific reductions in cue-induced cocaine craving. The neurobiological correlates of the chronic effects of cocaine have been well characterized by neuroimaging and quantitative EEG (qEEG) based studies. In addition, psychophysiological studies such as cue-induced cocaine craving provide a functional measure related to cocaine addiction. By combining qEEG measures with cue-induced cocaine craving studies this proposal will develop methods to examine the neurobiological basis of craving in cocaine addiction. The secondary aims of this proposal are to explore the relationships between cue-induced qEEG, psychophysiological and subjective responses, addiction severity and therapeutic outcome.