Chiral Catalysts by Rational Design

合理设计的手性催化剂

• 批准号: DP150103131
• 负责人: Prof Bernard Flynn
• 金额: $ 24.5万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-06-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP150103131
• 关键词: Chiral; Catalysts; Rational; Design

This project aims to integrate theory and experiment to design new catalysts for the synthesis of multi-stereocentre-containing molecules. Such molecules offer clear advantages in the area of drug design, owing to their potent and selective binding to biological targets, but a lack of available methods for their preparation currently limits their widespread use. This project will use theory to guide the discovery of new ways to make these molecules. It is expected that detailed understanding of the factors that control stereocentre formation will be obtained from accurate theoretical modelling and will be applied to invent new catalysts that deliver improved performance and control over product structure.

本计画旨在整合理论与实验，设计新型催化剂以合成多立构中心分子。这些分子在药物设计领域提供了明显的优势，因为它们与生物靶点的有效和选择性结合，但目前缺乏制备它们的可用方法，限制了它们的广泛使用。该项目将使用理论来指导发现制造这些分子的新方法。预计控制立构中心形成的因素的详细了解将从精确的理论建模中获得，并将被应用于发明新的催化剂，提供改进的性能和控制产品结构。