MEDICATIONS EFFECT ON TASTE AND SMELL IN HIV

描述(改编自摘要)：本研究的目的是 确定HIV感染患者使用的药物对 味觉和嗅觉。味觉和嗅觉明显丧失 发生在艾滋病毒感染中，这些损失可能导致食物不足 摄入会导致营养不良、体重减轻，最终导致消瘦。两者都有 实验数据和临床报告表明，药物起到了 在味觉和嗅觉损失中起主要作用。临床观察是有帮助的 在确定药物潜在的化学感官副作用方面；然而， 定量的实验研究是科学获取的必要条件。 关于使用药物造成的化学感觉损失的准确数据 化合物。调查员和她的同事将执行两个项目。 在项目I中，他们将评估药物对味觉的影响 通过将药物化合物局部应用于周围 无症状HIV感染者和匹配的未感染对照的舌头。 (这些研究是强制性的，因为药物被分泌到唾液中 可以改变味觉传导的浓度。)在项目II中，他们将 评价全身用药对味觉和嗅觉的影响 对早期HIV的感知。

DESCRIPTION (adapted from the Abstract): The purpose of this research is to determine the effect of medications used by HIV-infected patients on the senses of taste and smell. Significant losses in taste and smell perception occur in HIV infection, and these losses may contribute to inadequate food intake leading to malnutrition, weight loss, and ultimately wasting. Both experimental data and clinical reports indicate that medications play a major role in taste and olfactory losses. Clinical observations are helpful in determining potential chemosensory side effects of drugs; however, quantitative experimental studies are necessary to obtain scientifically accurate data on chemosensory losses resulting from use of pharmaceutical compounds. The Investigator and her associates will perform two projects. In Project I they will assess the effect of drugs on taste perception at the periphery by topical application of the pharmaceutical compounds to the tongue of asymptomatic HIV-infected persons and matched uninfected controls. (These studies are mandated because drugs are secreted into the saliva at concentrations that can modify taste transduction.) In Project II they will evaluate the effect of systemic use of medications on taste and smell perception in early HIV.