CANDIDA SECRETED ASPARTIC PROTEASES AS DRUG TARGETS

念珠菌分泌的天冬氨酸蛋白酶作为药物靶标

• 批准号: 2882240
• 负责人: ALICE M. CLARK
• 金额: $ 26.06万
• 依托单位: UNIVERSITY OF MISSISSIPPI
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-03-01 至 2001-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2882240
• 关键词: Candida; antifungal agents; aspartic endopeptidases; drug design /synthesis /production; drug screening /evaluation; plant extracts

DESCRIPTION (Adapted from the Investigator's Abstract): This proposal addresses inhibitors of Candida spp aspartic proteases as antifungal agents. The aims are to develop rapid screening procedures of Candida proteases from plant sources, evaluate plant extracts for protease inhibition, isolate and structurally characterize inhibitors from active plant extracts, characterize the mechanisms of inhibition of purified active natural products and design and synthesize second-generation inhibitors.

说明(改编自《调查员摘要》)：本提案 解决假丝酵母菌天冬氨酸蛋白酶抑制剂作为抗真菌药物 探员们。目的是建立念珠菌的快速筛查程序。 来自植物来源的蛋白酶，评估植物提取物中的蛋白酶 活性抑制剂的抑制、分离和结构表征 植物提取物，表征纯化的抑制作用的机制 活性天然产物与第二代设计合成 抑制剂。