HAIR CELL TRANSDUCTION IN A MAMMALIAN VESTIBULAR ORGAN

哺乳动物前庭器官中的毛细胞转导

• 批准号: 2890049
• 负责人: MELISSA A VOLLRATH
• 金额: $ 2.32万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-15 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2890049
• 关键词: afferent nerve; ear hair cell; laboratory mouse; mechanoreceptors; neural conduction; neural information processing; sensory receptors; vestibular apparatus; voltage /patch clamp; voltage gated channel

DESCRIPTION (Adapted from applicant's abstract): About 40 percent of Americans over 40 complain of dizziness at some time. In many cases, loss or damage of sensory cells in the inner ear is implicated. Dysequilibrium negatively impacts quality of life and productivity and can lead to depression and anxiety. Much remains unknown about the normal function of sensory cells in mammalian vestibular organs, which provide the input to reflexes that maintain balance and gaze. I propose to study stimulus processing by sensory cells in the mouse utricle. Hair cells, the sensory receptors of the inner ear, contain voltage and mechanically gated conductances that interact to shape the signals sent to the central nervous system. The mouse utricle contains two types of hair cells distributed throughout the organ. These cells are contacted by three types of vestibular afferents whose discharge properties vary systematically with the region of the utricle they innervate. The mechanisms underlying this regional organization are unknown, but are likely to include regional differences in the voltage and mechanically gated channels of hair cells. How the expression, voltage ranges of activation, or adaptation kinetics of these conductances vary is not known. Preliminary data show variations among utricular hair cells in ion channel expression, voltage ranges of activation and adaptation kinetics, but whether these or other differences are regionally organized is not known. This proposal aims to investigate whether hair cell properties vary with region and whether the differences observed explain differences in afferent firing properties.

描述（改编自申请人的摘要）：约 40% 40 岁以上的美国人有时会抱怨头晕。 在很多情况下，损失 或者内耳感觉细胞受损。 不平衡 对生活质量和生产力产生负面影响，并可能导致 抑郁和焦虑。 关于其正常功能仍有许多未知之处 哺乳动物前庭器官中的感觉细胞，为 保持平衡和凝视的反射。 我建议研究刺激 由小鼠椭圆囊中的感觉细胞进行处理。 毛细胞，感觉器官 内耳的感受器，包含电压和机械门控 相互作用形成发送到中枢神经的信号的电导 系统。 小鼠椭圆囊含有两种分布的毛细胞 整个器官。 这些细胞通过三种类型的接触 前庭传入神经的放电特性随 它们支配的椭圆囊区域。 这背后的机制 区域组织未知，但可能包括区域组织 毛细胞的电压和机械门控通道的差异。 激活的表达、电压范围或适应动力学如何 这些电导的变化尚不清楚。 初步数据显示存在差异 在椭圆囊毛细胞中离子通道表达中，电压范围为 激活和适应动力学，但是否有这些或其他差异 是否按地区组织尚不清楚。 本提案旨在调查 毛细胞特性是否因地区而异以及差异是否存在 观察到的现象解释了传入放电特性的差异。