X-RAY CRYSTALLOGRAPHY OF MACROMOLECULES

描述(摘自摘要)：该提案是为了可持续发展 HKL套装程序Denzo/Scalepack/XDisplayF用于数据缩减和 X-射线衍射数据的定标。新的发展领域落入三个 类别。推进阶段问题的解决将通过以下方式解决 硫磺单波长反常色散的最佳化 作为相位信息源的非同构以及一种方法的实现 对于CCD探测器的校准，广义吸收校正和 用于阶段化树分析的新界面。持续发展的方法 提高数据质量的目的是从以下方面获得有用的衍射数据 不是最理想的晶体。第三个发展领域将在 使最佳数据收集策略和数据归档标准化。

DESCRIPTION (Adapted from abstract): The proposal is for continued development of the HKL suite of programs Denzo/Scalepack/XDisplayF for data reduction and scaling of x-ray diffraction data. New areas for development fall in three categories. Advancing the solution of the phase problem will be addressed by optimization of single-wavelength anomalous dispersion from sulfur, use of nonisomorphism as a source of phase information, and implementation of a method for calibration for CCD detectors, a generalized absorption correction, and a new interface for phasing tree analysis. Continued development of methods for improving data quality will be aimed at obtaining useful diffraction data from less than optimal crystals. The third area for development will be in standardizing optimal data collection strategies and data archiving.