ESSENTIAL AMINO ACIDS AND SEIZURE SUSCEPTIBILITY

必需氨基酸和癫痫易感性

• 批准号: 2598100
• 负责人: DOROTHY W GIETZEN
• 金额: $ 16.11万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-04-01 至 2002-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2598100
• 关键词: calcium flux; dietary aminoacid; disease /disorder proneness /risk; electrophysiology; essential aminoacid; generalized seizures; hippocampus; isoleucine; laboratory rat; lateral olfactory area; microdialysis; neurotransmitters; nutrition related tag; protein deficiency

The aims of the proposal are to evaluate the duration of essential amino acid deficient diet required before increased seizures occur to determine by microdialysis whether neurotransmitters in the anterior piriform cortex are particularly affected and therefore plausibly involved in seizure susceptibility, and to determine whether treatment will effect the electrophysiologic responses of ta major projection from the anterior piriform cortex to the hippocampus which is thought to be important in seizure generation. The effect of essential amino acids in the anterior piriform cortex will be evaluated in vitro by assessing calcium flux and electrophysiologic measures in brain slices. And finally it is hoped that the seizures in a whole animal can be blocked by blocking the relevant neurotransmitter systems.

该提案的目的是评估必需氨基酸的持续时间， 在癫痫发作增加之前， 通过微透析确定前额叶中的神经递质 梨状皮质尤其受到影响， 参与癫痫易感性，并确定是否治疗 将影响TA主要投射的电生理反应， 海马体的梨状皮质前部， 在癫痫发作中很重要。 必需氨基酸的作用 在梨状前皮质中，将通过评估 脑切片中的钙流和电生理测量。 和 最后，希望可以阻断整个动物的癫痫发作， 通过阻断相关的神经递质系统。