ESSENTIAL AMINO ACIDS AND SEIZURE SUSCEPTIBILITY

该提案的目的是评估必需氨基酸的持续时间 在癫痫发作增加之前需要缺酸饮食 微透析法测定前额叶神经递质 梨状皮质受影响尤其严重，因此很有可能 参与癫痫易感性，并确定是否治疗 会不会影响Ta主要投射的电生理反应 梨状皮质到海马体的前部，被认为是 在癫痫的发生中很重要。人体必需氨基酸的作用 在梨状皮质的前部，将通过评估 脑片钙离子通量及电生理检测。和 最后，希望能阻止整个动物的癫痫发作。 通过阻断相关的神经递质系统。

The aims of the proposal are to evaluate the duration of essential amino acid deficient diet required before increased seizures occur to determine by microdialysis whether neurotransmitters in the anterior piriform cortex are particularly affected and therefore plausibly involved in seizure susceptibility, and to determine whether treatment will effect the electrophysiologic responses of ta major projection from the anterior piriform cortex to the hippocampus which is thought to be important in seizure generation. The effect of essential amino acids in the anterior piriform cortex will be evaluated in vitro by assessing calcium flux and electrophysiologic measures in brain slices. And finally it is hoped that the seizures in a whole animal can be blocked by blocking the relevant neurotransmitter systems.