IN VIVO 1HMRS STUDIES OF CEREBRAL INJURY IN HIV DEMENTIA

HIV 痴呆脑损伤的体内 1HMRS 研究

• 批准号: 2685780
• 负责人: BRADFORD NAVIA
• 金额: $ 52.24万
• 依托单位: TUFTS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-04-01 至 2000-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2685780
• 关键词: AIDS; AIDS dementia complex; HIV infections; antiAIDS agent; aspartate; basal ganglia; brain injury; choline; clinical research; cognition disorders; frontal lobe /cortex; human subject; human therapy evaluation; neuropsychological tests; nuclear magnetic resonance spectroscopy

This is an ambitious proposal for a 3 year multicenter study that will involve at least 12 sites. Using in vivo 1H-MRS, this consortium will explore hypotheses that relate various patterns of CNS cellular injury in individuals with HIV infection. The aims are: 1) To quantify regional levels of NAA, Cho, MI in the HIV-infected brain in a well defined cohort of subjects with ADC; 2) To correlated regional measurements of cellular metabolites with severity of neurocognitive impairment and systemic disease; 3) To examine the relationship of neurotoxicity, 1H-MRS results and neuropsychological testing; and 4) To determine the effects of memantine on the content of these performance. This consortium will study: (1) 80 subjects with mild or moderate dementia, enrolled in a randomized double-blind controlled trial of memantine act baseline and week 16; 2) 40 seropositive neurologically asymptomatic subjects with CD4 counts less than 200, and 3) 40 age-matched seronegative controls. Proton spectra will be obtained using a short echo STEAM sequence from the parietal cortex, the frontal centrum semiovale, and the basal ganglia. Metabolites from these regions will be quantified as ratios and absolute measurements and correlated with the severity of ADC and systemic disease, CSF/peripheral studies of surrogate markers and viral burden, and response to memantine and background antiretroviral therapy.

这是一项为期 3 年的多中心研究的雄心勃勃的提案， 至少涉及12个站点。 利用体内 1H-MRS，该联盟将 探索与中枢神经系统细胞损伤的各种模式相关的假设 HIV 感染者。 目标是： 1) 量化 井中 HIV 感染大脑中 NAA、Cho、MI 的区域水平 定义的 ADC 受试者队列； 2) 相关区域 细胞代谢物与神经认知严重程度的测量 损伤和全身性疾病； 3）检查关系 神经毒性、1H-MRS结果和神经心理学测试；和 4) 确定美金刚对这些物质含量的影响 表现。 该联盟将研究：(1) 80 名患有轻度或 中度痴呆症，参加了一项随机双盲对照研究 美金刚试验基线和第 16 周； 2) 40 例血清反应呈阳性 CD4 计数低于 200 的无神经症状受试者， 3) 40 名年龄匹配的血清阴性对照。 质子谱将是 使用来自顶叶的短回波 STEAM 序列获得 皮质、半卵圆额叶中心和基底神经节。 这些区域的代谢物将被量化为比率和 绝对测量值并与 ADC 的严重程度相关 全身性疾病、替代标记物和病毒的脑脊液/外周研究 负担以及对美金刚和背景抗逆转录病毒药物的反应 治疗。