SURVIVAL AND AGE AT DIAGNOSIS OF BREAST CANCER

描述：(改编自《调查者摘要》)关系 乳腺癌的治疗效果与确诊年龄之间的关系 长期以来，疾病一直都是有争议的，现在仍然是。评估……的效果 年龄和其他个体特征对确诊的女性存活率的影响 乳腺癌我们建议通过扩展的武器库来解决这个问题 生存分析的现代统计方法。在此过程中，我们将使用数据 关于通过SEER计划确定的乳腺癌患者。这个 在这项以人口为基础的研究中，首要考虑的将是估计 不同类型女性心绞痛患者的危险函数及治愈率 特别强调不同年龄层之间的差异。对预后的意义 发现乳腺癌时的年龄将使用回归分析进行研究 非参数平滑技术和参数过程的对应物 设计用于估计危险函数。这些方法提供了一种方法 用年龄和其他协变量的主导作用来解释它们的影响 对肿瘤治愈概率(存活分数)或对 故障发生的时间。这样的解释提供了更深层次的 对影响当前临床治疗效果的因素的洞察 治疗方法。

DESCRIPTION: (Adapted from the Investigator's Abstract) The relationship between the efficacy of treatment for breast cancer and age at diagnosis of the disease has long been and still remains controversial. To assess the effect of age and other individual characteristics on survival of women diagnosed with breast cancer we propose to attack the problem with an extended arsenal of modern statistical methods of survival analysis. In doing so, we will use data on patients with breast cancer identified through the SEER Program. The foremost consideration in this population-based study will be estimation of the hazard function and cure rates for different categories of female patients with special emphasis on variations across age strata. The prognostic significance of age at detection of breast cancer will be studied using regression counterparts of nonparametric smoothing techniques and parametric procedures designed for estimation of the hazard function. These methods offer a way to interpret the effect of age and other covariates in terms of their predominant influence either on the probability of tumor cure (surviving fraction) or on the timing of failure occurrence. Such an interpretation provides a deeper insight into factors determining clinical outcome of currently practiced treatment methods.