CYTOTOXIC T LYMPHOCYTE ACTIVATION IN VITRO AND IN VIVO

体外和体内细胞毒性 T 淋巴细胞激活

• 批准号: 2758867
• 负责人: MATTHEW Franklin MESCHER
• 金额: $ 19.7万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-07-01 至 2003-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2758867
• 关键词: MHC class I antigen; T cell receptor; artificial membranes; cytokine; cytokine receptors; cytotoxic T lymphocyte; genetically modified animals; immunologic memory; interleukin 12; interleukin 2; laboratory mouse; leukocyte activation /transformation; passive immunization; receptor expression; tissue /cell culture

DESCRIPTION: (Adapted from the applicant's abstract) In this application, Dr. Mescher proposes to continue his studies identifying ligands that are essential for the activation of naive and memory cytotoxic T lymphocytes. Utilizing both his pioneering system of artificial surfaces for the delivery of defined signals and an adoptive transfer of CTLs from transgenic TCR mice, Dr. Mescher proposes to confirm much of his preliminary work identifying the key signals responsible for triggering CTL activation. This renewal application is expanded to include experiments to define the potential role that IL-12 plays in activating the naive CTL response as well as investigating a potential role for inflammatory cytokines in influencing memory cell function. Two specific aims, which are essentially identical to the specific aims of the original project, with the important addition of the adoptive transgenic mouse system are proposed.

描述：（改编自申请人的摘要）在此