LOCAL CEREBRAL GLUCOSE UTILIZATION AND ALCOHOL RELAPSE

局部脑葡萄糖利用和酒精戒酒

• 批准号: 2707837
• 负责人: DANIEL G SMITH
• 金额: $ 2.08万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-02-28 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2707837
• 关键词: alcoholism /alcohol abuse; behavioral /social science research tag; brain metabolism; drug withdrawal; ethanol; glucose metabolism; laboratory rat; male; neuropharmacology; psychopharmacology; relapse /recurrence

DESCRIPTION: The long-range goal of this proposal is to identify CNS sites involved in mediating the alcohol deprivation effect (ADE). The long-term ADE is characterized by an increase in baseline alcohol consumption following a deprivation period of one week or longer. The hypothesis of the present proposal is that neuroadaptations occur during a long-term alcohol deprivation which follows chronic alcohol consumption. The [14C]-2-deoxyglucose technique will be used to measure rates of local cerebral glucose utilization (LCGU) to identify CNS regions involved in the alcohol relapse. Adult male rats from the selectively bred alcohol-preferring P line will be used since they readily demonstrate an ADE after deprivation periods of one week and four weeks, following chronic 24-hour alcohol drinking. The specific aims of this study are to establish the existence of a long-term ADE in animals on a 1-hour scheduled access paradigm and determine LCGU changes associated with the alcohol relapse. The overall purpose of this research is to improve the current understanding of the neurobiological mechanisms underlying alcohol relapse.

产品说明： 该提案的长期目标是确定涉及以下方面的CNS位点： 酒精剥夺效应（ADE）。 长期ADE是 其特征是基线饮酒量增加， 剥夺一周或更长时间。 现在的假设 一个假设是，神经适应发生在长期饮酒的过程中。 长期饮酒后的剥夺。 的 [14 C]-2-脱氧葡萄糖技术将用于测量局部 脑葡萄糖利用（LCGU）来识别参与脑葡萄糖代谢的中枢神经系统区域 酒精复发 成年雄性大鼠从选择性繁殖 将使用偏好酒精的P系，因为它们容易证明ADE 在一周和四周的剥夺期后， 24-小时饮酒。 本研究的具体目的是建立 在1小时计划入路的动物中存在长期ADE 范式，并确定与酒精复发相关的LCGU变化。 本研究的总体目的是为了提高目前的认识， 酒精复发的神经生物学机制