RENOVATION OF SHM BWING, 3RD FLOOR

该提案要求为全面翻修提供资金， 约11，224平方英尺的研究空间在斯特林大厅， 耶鲁大学医学院。这个空间只占不到一半 分配到药理学系。没有进行任何翻新 如果这些实验室中的许多自1965年以来， 条件差。药理学系的研究福尔斯属于 神经药理学、信号转导与肿瘤 药理学对拟议空间的重新设计将汇集 神经药理学的研究人员，他们非常关注 离子通道的分子、生物物理和调节特性， 运输机该领域的教师是芭芭拉埃利希（生物物理 细胞内膜上钙释放通道的性质， 它们通过第二信使的调节），艾德莫奇德洛斯基（生物物理学 钙激活钾通道和电压依赖性钠通道 通道），加里鲁德尼克（神经递质转运蛋白的功能）， Priscilla Dannies（垂体细胞中肽分泌的调节）， Murdoch里奇（离子通道在神经胶质细胞中的作用）和伦纳德 Kaczmarek（通过调节神经元兴奋性的长期变化） 蛋白激酶和基因表达的变化）。拟议的计划将 允许这些研究人员共享开放式实验室， 因此，鼓励直接交流信息，正式合作， 以及博士后和学生的联合指导。

This proposal requests funds towards a complete renovation and approximately 11,224 square feet of research space in the Sterling Hall of Medicine of Yale University. The space represents just under half of that assigned to the Department of Pharmacology. There has been no renovation if many of these laboratories since 1965, and as a result much of it is in poor condition. Research in the department of pharmacology falls into three main ares, neuropharmacology, signal transduction and cancer pharmacology. The redesign of the proposed space would bring together the investigators in neuropharmacology, who have a strong focus on the molecular, biophysical and regulatory properties of ion channels and transporters. The faculty in this area are Barbara Ehrlich (biophysical properties of calcium release channels on intracellular membranes and their regulation by second messengers), Ed Moczydloski (biophysics of calcium-activated potassium channels and voltage-dependent sodium channels), Gary Rudnick (function of neurotransmitter transporters), Priscilla Dannies (regulation of peptide secretion in pituitary cells), Murdoch Ritchie (role of ion channels in glial cells) and Leonard Kaczmarek (regulation of prolonged changes in neuronal excitability by protein kinases and changes in gene expression). The proposed plan would allow these investigators to share open-plan laboratories, and would therefore encourage direct exchange of information, formal collaborations, and joint-mentoring of post-docs and students.