EXTRAMURAL RESEARCH FACILITIES CONSTRUCTION

维克森林大学医学院是一家国际性的 在使用非人类灵长类动物研究人类疾病方面处于领先地位。四个人 几十年来，我们一直在利用非人类灵长类动物模型来研究生物 不同疾病状态的基础，包括动脉粥样硬化， 卵巢病理学、药物滥用、衰老和周围神经损伤。完毕 在过去的五年里，WFUSM采用了功能成像 正电子发射断层扫描技术在神经生物学研究中的应用 非人灵长类动物行为的相关性。这项计划包含了 放射科教员的跨部门努力， 生理学与药理学、比较医学、麻醉学和 神经生物学与解剖学。正电子发射计算机断层成像技术在行为学研究中的应用 对慢性疾病的灵长类动物模型的研究是独一无二的。快速增长 该计划的实施反映了该方法的独特性和 这项研究对美国国立卫生研究院任务的重要性。然而，这种增长也 限制了我们支持其他NIH资助的科学项目的能力， 并导致非人类灵长类动物的运输增加 在WFUSM的三个不同的校区。世界银行的目标是 校外科研设施建设项目：1)巩固 研究人员在行为研究中使用PET的研究方案 使用人类疾病的非人类灵长类模型的计划；2)提供 一种机制，将促进其他国家创新使用PET WFUSM的研究人员，3)允许其他非人类灵长类动物生长 利用行为的不同神经生物学相关性进行的研究，以及4) 通过限制校际学习确保PET研究的科学完整性 将猴子运送到宠物中心。

The Wake Forest University School of Medicine (WFUSM) is an international leader in the use of non-human primates to study human disease. For four decades we have utilize non-human primate models to study the biological basis of diverse disease states, including atherosclerosis, oestopathology, substance abuse, aging, and peripheral nerve injury. Over the past five years, the WFUSM has adapted the functional imaging technique Positron Emission Tomography (PET) to study the neurobiological correlates of behavior in non-human primates. This program incorporates cross-departmental efforts of faculty in the Departments of Radiology, Physiology & Pharmacology, Comparative Medicine, Anesthesiology and Neurobiology & Anatomy. The incorporation of PET imaging into behavioral studies of primate models of chronic disease is unique. The rapid growth of this Program reflects the uniqueness of this approach and the importance of this research to the NIH mission. However, this growth also has limited our ability to support other NIH-funded scientific programs, and has resulted in an increased transportation of non-human primates across the three separate campuses of the WFUSM. The goals of the Extramural Research Facilities Construction Project are to 1) consolidate the research programs of investigators using PET in behavioral research programs employing non-human primate models of human disease; 2) provide a mechanism that will facilitate the innovate use of PET by other investigators at the WFUSM, 3) allow the growth of other non-human primate studies utilizing different neurobiological correlates of behavior, and 4) insure the scientific integrity of PET studies by limiting intercampus transportation of monkeys to the PET Center.