SELF CONTROL IN DRUG SELF ADMINISTRATION

药物自我管理中的自我控制

• 批准号: 6054244
• 负责人: Karen G Anderson
• 金额: $ 3.67万
• 依托单位: UNIVERSITY OF MISSISSIPPI MED CTR
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-01-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6054244
• 关键词: Macaca mulatta; barbiturates; behavioral /social science research tag; choice; cocaine; disease /disorder model; dosage; drug interactions; impulsive behavior; intravenous drug abuse; psychological models; reinforcer; self medication

Self-control is frequently defined behaviorally as a choice for a larger, delayed reinforcer over a smaller, more immediate reinforcer. Impulsivity is the converse of self-control and characterizes impulse disorders like drug abuse. An understanding of the factors that determine an individual's impulsive or self- control choices, and how drugs affect those choices, is crucial to the development of behavioral and pharmacological interventions for many behavioral disorders, including drug abuse. The purpose of this research proposal is to examine the effects of reinforcement magnitude and delay on drug taking using an established model of self-control. Rhesus monkeys working in a discrete-trials procedure will be allowed to self-administer different doses of a stimulant, cocaine (Experiment 1) or a depressant, methohexital (Experiment 2) with different sets of delays to drug infusion. A quantitative description of the data obtained in different drug reinforcement contexts will be possible and will allow examination of the self- control model for behavior maintained by drugs. Further, the experiments will examine the generality of findings from non-drug contexts. Such information has relevance to the understanding of choice in general, and ultimately to the potential development of treatments for, or prevention of, drug abuse.

自我控制在行为上经常被定义为选择更大、延迟的强化物而不是更小、更直接的强化物。冲动是自我控制的反面，是药物滥用等冲动障碍的特征。了解决定个人冲动或自我控制选择的因素，以及药物如何影响这些选择，对于制定针对包括药物滥用在内的许多行为障碍的行为和药物干预措施至关重要。本研究计划的目的是使用已建立的自我控制模型来检查强化幅度和延迟对药物服用的影响。进行离散试验程序的恒河猴将被允许自行注射不同剂量的兴奋剂可卡因（实验 1）或抑制剂美索比妥（实验 2），并延迟不同组的药物输注。对在不同药物强化环境中获得的数据进行定量描述将是可能的，并且将允许检查药物维持的行为的自我控制模型。此外，实验将检验非药物环境中发现的普遍性。这些信息与对一般选择的理解相关，并最终与药物滥用治疗或预防的潜在开发相关。