VAGAL TONE AND SOCIAL OUTCOME IN AT RISK CHILDREN

高危儿童的迷走神经张力和社会结果

• 批准号: 6014545
• 负责人: STEPHEN J SHEINKOPF
• 金额: $ 3.03万
• 依托单位: EMMA PENDLETON BRADLEY HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-08-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6014545
• 关键词: autonomic reflex; behavioral /social science research tag; caregivers; child rearing; clinical research; disease /disorder proneness /risk; embryo /fetus toxicology; heart function; heart innervation; heart rate; human subject; infant human (0-1 year); longitudinal human study; prenatal stress; preschool child (1-5); social behavior; social behavior disorders; vagus nerve

DESCRIPTION: (Applicant's Abstract) Utilizing a longitudinal design and drawing subjects from a large ongoing study, this investigation will examine the relations between cardiovascular reactivity in infancy and social and behavioral outcomes in an at-risk group of children. In so doing, the study will examine the predictive role of cardiac reactivity (i.e., vagal tone) to specifically social stimuli in infancy to specifically social outcomes at 3-years of age. In addition, this study will investigate the role of caregiver stress and dysfunction in potentially moderating the relations between infant cardiac reactivity and 3-year outcome. To date, few if any studies have examined relations between cardiac reactivity and behavioral outcome in at-risk children. Participants will include approximately 1,000 drug-exposed children who have been observed on a regular basis from birth through three years of age. The design is longitudinal and will utilize measures from three separate domains: cardiac reactivity in infancy, 2) a cumulative index of risks present in the caregiving environment, and 3) a cumulative index of social and behavioral risk outcomes at 3-years of age. Analyses will address two main goals. First, domain-specific relations between cardiac reactivity to social and nonsocial events in infancy and social and nonsocial competence in preschool will be examined. Second, the relation of caregiving risk to social and behavioral outcomes will be examined. In particular, this second set of analyses will examine the potential interaction of cardiac reactivity and caregiving factors in predicting social and behavioral outcomes.

描述：(申请人摘要)采用纵向设计，从一项正在进行的大型研究中抽取受试者，这项研究将检验婴儿期心血管反应性与高危儿童的社会和行为结果之间的关系。在此过程中，这项研究将检验心脏反应性(即迷走神经张力)对婴儿期特定社会刺激的预测作用，以及对3岁时特定社会结果的预测作用。此外，这项研究将调查照顾者压力和功能障碍在潜在地缓和婴儿心脏反应性和3年预后之间的关系中的作用。到目前为止，很少有研究考察高危儿童的心脏反应性和行为结果之间的关系。参与者将包括大约1000名接触毒品的儿童，他们从出生到三岁都被定期观察。该设计是纵向的，将利用三个不同领域的衡量标准：婴儿期的心脏反应性，2)照料环境中存在的风险的累积指数，以及3)3岁时社会和行为风险结果的累积指数。分析将涉及两个主要目标。首先，将考察婴儿期心脏对社交和非社交事件的反应性与学龄前儿童的社交和非社交能力之间的特定领域的关系。其次，我们将考察照料风险与社会和行为结果之间的关系。特别是，这第二组分析将检验心脏反应性和护理因素在预测社会和行为结果方面的潜在交互作用。