OPTIMIZING IMMUNOTHERAPY OF RENAL CELL CANCER

优化肾细胞癌的免疫治疗

• 批准号: 2896208
• 负责人: MARY Alice MALUCCIO
• 金额: $ 3.85万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-30 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2896208
• 关键词: CD28 molecule; CD3 molecule; antibody specificity; cytotoxic T lymphocyte; drug screening /evaluation; flow cytometry; gene expression; interleukin 2; kidney neoplasms; laboratory mouse; leukocyte activation /transformation; monoclonal antibody; neoplasm /cancer immunotherapy; nonhuman therapy evaluation; polymerase chain reaction

项目成果

Dendritic cells armed with anti-CD3 mAbs reduce pulmonary metastases, prolong survival, and engender antitumor effector cells demonstrable by adoptive transfer.

配备抗 CD3 mAb 的树突状细胞可减少肺转移、延长生存期，并产生可通过过继转移证明的抗肿瘤效应细胞。

• DOI: 10.1007/s10434-000-0771-9
• 发表时间: 2000
• 期刊: Annals of surgical oncology
• 影响因子: 3.7
• 作者: Maluccio,MA;Rao,J;Sharma,V;Lagman,M;Suthanthiran,M
• 通讯作者: Suthanthiran,M