EPIDEMIOLOGY OF HUMAN RETROVIRUSES IN BLOOD DONORS

献血者中人类逆转录病毒的流行病学

• 批准号: 2879236
• 负责人: MARTHA HIGGENS
• 金额: $ 88.9万
• 依托单位: AMERICAN NATIONAL RED CROSS SE MICHIGAN
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-07-17 至 2003-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2879236
• 关键词: AIDS; Retroviridae; antiviral antibody; blood donor; disease /disorder proneness /risk; ethnic group; gender difference; human T cell lymphotropic virus type 1; human T cell lymphotropic virus type 2; human age group; human immunodeficiency virus 1; human immunodeficiency virus 2; human subject; longitudinal human study

The objective of this contract are as follows: 1) determine the prevalence of retrovirus seropositivity in first time blood donors; 2) determine the rate of retrovirus seroconversion in repeat blood donors as a measure of incidence of infection; 3) ascertain risk factors for antibody-positive donors; 4) characterize the blood donor population by geographic location, age, sex, race/ethnicity, and donation history to permit analysis on prevalence, incidence, and risk factors; 5) identify recipients of retrovirus-positive blood units and conduct clinical and laboratory follow-up of these recipients to determine the transmissibility of these agents via transfusion; and 6) establish blood specimen repositories for long-term storage of specimens from study donors and recipients for future testing.

本合同的目标如下： 1) 确定 首次献血者逆转录病毒血清阳性的患病率； 2） 将重复献血者的逆转录病毒血清转化率确定为 感染发生率的衡量标准； 3) 确定风险因素 抗体阳性捐献者； 4) 描述献血者群体的特征 地理位置、年龄、性别、种族/民族以及捐赠历史 允许对患病率、发病率和危险因素进行分析； 5）识别 逆转录病毒阳性血液单位的接受者并进行临床和 对这些接受者进行实验室随访以确定 这些药物可通过输血传播； 6）建立血液 用于长期储存研究样本的样本库 捐赠者和接受者进行未来的测试。