UROLOGICAL RESEARCH TRAINING FOR BASIC SCIENTISTS

本提案支持培养博士后科学家成为致力于研究泌尿生殖系统疾病的独立研究者。该计划是协调和共同管理与类似的努力培训委员会合格的泌尿科医生在泌尿科调查。培养一小部分高素质的博士科学家从事与泌尿生殖系统疾病相关的当代研究是一项投资，对国家当前和未来的卫生保健需求至关重要。肾脏和泌尿生殖系统疾病影响了超过1300万美国人，这个数字在不久的将来可能会增加。我们的培训计划培养能够应对这一医学挑战的科学家，为他们配备适当的现代研究工具和有效的知识基础，以便他们能够揭示泌尿生殖系统疾病的机制。细胞和分子生物学的实验工具和知识发现为预防、治疗和控制，甚至在某些情况下治愈泌尿生殖系统的疾病创造了令人兴奋的新可能性。培训计划是量身定制的，以适应来自不同学术背景的学员：在生物统计学，细胞生物学和重组DNA技术方面提供正式的指导，目标是培养全面发展的跨学科科学家。由临床研究人员和基础科学家组成的协调团队在特定兴趣领域提供具体指导，确保跨学科发展与研究培训并行。所有导师都在医学院获得终身或终身职位，指导至少一项活跃的研究经费，并具有培养博士后科学家从事生产性职业的经验。学院的环境提供了丰富的研讨会、客座教授和会议，促进了学员和导师之间的交流。主要研究方向包括：平滑肌挛缩的分子生理学和药理学、睾丸及其排泄管的病理生理学、前列腺生长控制和癌症、梗阻性疾病的神经泌尿学、生长因子在神经肌肉相互作用中的作用、泌尿生殖疾病的神经、血管和免疫机制以及梗阻性肾脏病理。弗吉尼亚大学医学院致力于为临床研究人员和基础科学家在泌尿科关键疾病机制方面的新研究提供富有成效的共同基础，从而为基础科学家在泌尿科重要疾病机制方面的新研究提供跨学科培训。

This proposal support for the training of post-doctoral scientists for careers as independent investigators committed to studying diseases of the genitourinary system. The program is coordinated and co-administered with a similar effort training board-eligible urologists in urological investigation. Training of a small but highly qualified subset of Ph.D. scientists to pursue contemporary research relevant to diseases of the urogenital system is an investment that is essential to the nation's current and future health care needs. Diseases of the kidneys and urogenital system affect more than 13 million Americans and this number may increase in the near future. Our training program develops scientists who can meet this medical challenge by equipping them appropriately with modern research tools and an effective knowledge base so they can unravel the mechanisms of urogenital disorders. The experimental tools and intellectual discoveries of cell and molecular biology have generated exciting new possibilities for the prevention, treatment, and control and, in some cases, cure of afflictions of the genitourinary system. The training program is tailored to accommodate trainees from diverse from diverse academic backgrounds: formal instruction is available in biostatistics, cell biology, and recombinant DNA technology with the goal of producing well-rounded, inter- disciplinary scientists. Specific mentoring by coordinated teams of clinician-investigators and basic scientists in specific interest areas ensures cross-disciplinary development in parallel with research training. All mentors hold tenured or tenure-track appointments in the School of Medicine, direct at least one active research grant, and have experience in training postdoctoral scientists for productive careers. The institutional environments offers a rich mixture of seminars, visiting professors and conferences that creatures stimulating exchanges among trainees and mentors. The primary focus of faculty research programs includes: molecular physiology and pharmacology of smooth muscle contracture, pathophysiology of the testis and its excurrent ducts, prostate growth control and cancer, neuro-urology of obstructive disorders, role of growth factors in neuromuscular interaction, neural, vascular and immunological mechanisms of urogenital disease and obstructive renal pathology. Interdisciplinary training of basic scientists in promising research relevant to urological disease follows the University of Virginia Medical School's commitment to foster a productive common ground for clinical investigators and basic scientists to exploit novel research in critical disease mechanisms in urology.