INTEGRATING PHYSIOLOGY AND BEHAVIOR IN REAL TIME FMRI

将生理学和行为整合到实时 FMRI 中

• 批准号: 6142622
• 负责人: JAMES T VOYVODIC
• 金额: $ 9.94万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-07-01 至 2003-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6142622
• 关键词: bioimaging /biomedical imaging; brain imaging /visualization /scanning; clinical research; cognition; computer program /software; diagnosis design /evaluation; diagnosis quality /standard; electroencephalography; functional magnetic resonance imaging; human subject; method development; noninvasive diagnosis; physiology; statistics /biometry

DESCRIPTION: Functional magnetic resonance imaging (fMRI) has enormous potential for both scientific and clinical studies of human brain function. For diagnostic radiology, fMRI's ability to localize functional areas non-invasively promise to make it an especially important tool in presurgical planning for epilepsy and brain tumors. To make this technology practical, however, it must be more reliable than currently available. To accomplish this, fMRI must have high spatial and temporal resolution, good paradigm control, appropriate statistica analysis, and rapid data processing. Another important practical consideration is that fMRI needs to be able to yield results even under less than ideal subject performance conditions. In clinical studies, patients are typically no extensively trained in their tasks and tend to be highly variable in their performance. Scan reliability and spatial resolution can be effectively improved by explicitly separating MR signal changes associated with task performance, away from signal changes attributable to other physiological, behavioral, electrical, or mechanical variables. The Principal Investigator (PI) has developed real-time paradigm control software and real-time image analysis software for fMRI that generalize this strategy for improving scan quality by allowing many different behavioral and physiological variables to be integrate simultaneously. An important aspect of this approach is that all the analysis is performed in close to real-time, so that the complete results are available during the scan or within a minute after scan completion. This immediate feedback provides quality assurance that greatly improves scan reliability. Fo clinical scans, such timely results are critical if fMRI is to be used to tailor treatment to individual patients. The current application seeks support to apply and extend this work to identif optimal software strategies for improving the effective sensitivity and resolution of clinical and research fMRI. This project tests the hypothesis that physiological and behavioral data improves task-specific signal-to-noise ratio and spatial resolution. Subjective behavioral responses will be tested a probes of cognitive brain function. Practical strategies for obtaining comprehensive fMRI results in close to real-time will be investigated. Integrating the strategies addressed in this study will make fMRI a more sensitive and reliable brain imaging tool, thereby extending its capabilities for a wide range of both scientific and clinical applications.

产品说明： 功能性磁共振成像（fMRI）在这两方面都有巨大的潜力 人类大脑功能的科学和临床研究。 用于诊断 放射学，功能磁共振成像的能力，定位功能区非侵入性 承诺使其成为手术前计划中特别重要的工具， 癫痫和脑瘤 然而，为了使这项技术实用化， 必须比现在更可靠。 为了实现这一点，fMRI 必须具有高的空间和时间分辨率，良好的范例控制， 适当的光谱分析和快速的数据处理。 另一 重要的实际考虑是，功能磁共振成像需要能够产生 即使在不太理想的对象性能条件下也能产生结果。 在 在临床研究中，患者通常没有经过广泛的培训， 任务，往往是高度可变的，在他们的表现。 扫描可靠性和空间分辨率可以通过以下方式有效地提高： 明确分离与任务表现相关的MR信号变化， 远离可归因于其它生理，行为， 电气或机械变量。 主要研究者（PI） 开发了实时范例控制软件和实时图像分析 用于功能磁共振成像软件，其推广了这种策略以提高扫描质量 通过允许许多不同的行为和生理变量， 同时整合。 这种方法的一个重要方面是， 该分析接近实时地执行，使得完整的 扫描期间或扫描后一分钟内可获得结果 建成 这种即时反馈提供了质量保证，极大地 提高扫描可靠性。 对于临床扫描来说，这样及时的结果是 如果功能性磁共振成像是用来定制治疗个别病人至关重要。 目前的申请寻求支持，以应用和扩展这项工作， 确定提高有效灵敏度的最佳软件策略 以及临床和研究功能磁共振成像的分辨率。 该项目测试了 假设生理和行为数据改善了特定任务 信噪比和空间分辨率。 主观行为 反应将被测试为认知脑功能的探针。 实际 获得接近实时的全面功能磁共振成像结果的策略 将进行调查。 整合本研究中提出的战略 将使fMRI成为一种更灵敏、更可靠的大脑成像工具， 扩展其在科学和临床领域的能力 应用.