HIV, TB, HSV 2--EMERGENCE OF DRUG RESISTANCE

HIV、TB、HSV 2——耐药性的出现

• 批准号: 2887591
• 负责人: Sally Margaret Blower
• 金额: $ 30.14万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-05-01 至 2001-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2887591
• 关键词: HIV infections; Herpes simplex disease; Mycobacterium tuberculosis; clinical research; communicable disease transmission; disease /disorder prevention /control; drug resistance; herpes simplex virus 2; human immunodeficiency virus; human subject; mathematical model; model design /development; tuberculosis

Description (adapted from the Abstract): The overall objective of this project is to develop and apply mathematical models to design control strategies that will reduce morbidity and mortality while simultaneously reducing the impact of drug resistance when controlling epidemics of the human immunodeficiency virus (HIV), Mycobacterium tuberculosis (TB), and herpes simplex virus-2 (HSV-2). The project brings together a community of researchers that includes both mathematical modelers and infectious disease experts. The aims are to (1) formulate a series of disease specific mathematical models that reflect the transmission dynamics of drug-sensitive and drug-resistant pathogens in a treated population, (2) (a) predict incidence and prevalence of drug resistance, and (b) identify which biological, behavioral, or treatment factor are most important in contributing to the emergence and transmission of drug resistance,, and (3) (a) design control strategies, (b) develop evaluation criteria, and 8 use the criteria to evaluate tradeoffs among medical and behavioral interventions when designing and improving control strategies. HIV control strategies will be designed for HIV-infected gay communities in which combination therapies are used, as well as vaccines. TV control strategies are based on vaccinations, chemoprophylaxis, chronic suppression, and potential vaccines. The researchers will also consider the potential effects if the HIV epidemic on causing increased morbidity, mortality, and levels of drug resistance to both TV and HSV-2.

描述（改编自摘要）：本报告的总体目标 项目是开发和应用数学模型来设计控制 降低发病率和死亡率，同时 减少耐药性的影响， 人类免疫缺陷病毒（HIV）、结核分枝杆菌（TB），以及 单纯疱疹病毒2型（HSV-2）。该项目汇集了一个社区， 研究人员，包括数学建模和传染病 疾病专家目的是（1）制定一系列疾病 具体的数学模型，反映了传输动态的 治疗人群中的药物敏感和耐药病原体，（2） (a)预测耐药性的发生率和流行率，以及（B）鉴定 哪种生物学、行为学或治疗因素在 有助于耐药性的出现和传播，以及 (3)（a）设计控制策略，（B）制定评估标准，以及8 使用该标准来评估医疗和行为之间的权衡 在设计和改进控制策略时采取干预措施。艾滋病毒控制 将为艾滋病毒感染的同性恋社区制定战略， 使用联合疗法以及疫苗。电视控制策略 是基于疫苗接种，化学预防，慢性抑制， 潜在的疫苗研究人员还将考虑 艾滋病毒流行对造成发病率、死亡率和 对TV和HSV-2的耐药性水平。