REPRODUCTIVE/CONTRACEPTIVE RISK FACTORS & ENDOMETRIOSIS

生殖/避孕风险因素

• 批准号: 2908595
• 负责人: Victoria L Holt
• 金额: $ 10.42万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-05-01 至 2002-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2908595
• 关键词: adolescence (12-20); age at pregnancy; behavioral /social science research tag; clinical research; contraceptives; data collection methodology /evaluation; disease /disorder proneness /risk; embryo /fetus death; endometriosis; female reproductive system disorder diagnosis; human population study; human subject; induced abortion; interview; menstrual cycle; nondrug contraceptive; oral contraceptives; reproduction; sex behavior; sex sterilization; spontaneous abortion; statistics /biometry; ultrasonography; women's health; young adult human (21-34)

Endometriosis affects up to 10% of women of reproductive age in the U.S. with chronic pelvic pain, dysmenorrhea, and probable increased risk of infertility. Although the disease has been identified as a top research priority by the National Institutes of Health, the etiology is still uncertain, and few modifiable risk factors have been identified. Past epidemiologic research has been inconclusive about the impact of reproductive or contraceptive history on the development of endometriosis. Most studies of these risk factors have been limited by using cases identified at infertility surgery, as these women may be atypical of all endometriosis cases in terms of reproductive and contraceptive history. We propose a population-based case-control study of endometriosis among the entire population of reproductive-age women enrolled in an HMO in western Washington State to test the hypothesis that spontaneous abortion and induced abortion may increase risk of endometriosis, taking into account possible hormonal and immunological influences. The associations between endometriosis and delayed childbearing and various types of contraception will be investigated as well. All 18-44 year old enrollees of Group Health Cooperative of Puget Sound (GHC) diagnosed with endometriosis by surgery, and a portion of those diagnosed by physical examination or ultrasound examination alone between August l, 1996 and April 30, 2001 will be identified and invited to participate (approximately 750 women of all races). Cases will be selected using computerized records, and eligibility verified by medical records. Controls randomly selected from computerized enrollment files will be frequency matched to cases on age and primary care clinic region. Data will be obtained from cases and controls by in-person interview, and anthropometric measurement; and linked with the GHC computerized pharmacy database. Subjects will be interviewed regarding their reproductive and contraceptive histories; including spontaneous and induced abortions, stillbirths, livebirths, use of hormonal contraceptives, intrauterine devices, and sterilization procedures; menstrual history; infertility history; and other risk factors for endometriosis.

子宫内膜异位症影响了美国高达10%的育龄妇女。 慢性盆腔疼痛，痛经，可能增加的风险， 不孕虽然这种疾病已被确定为顶级研究 由美国国立卫生研究院优先，病因仍然是 不确定的，很少有可改变的风险因素已经确定。过去 流行病学研究一直没有确定的影响， 生殖或避孕史对发展的影响 子宫内膜异位症大多数关于这些危险因素的研究都受到以下限制： 使用不孕症手术中确定的病例，因为这些妇女可能 子宫内膜异位症的所有病例中， 避孕史我们提出了一个基于人群的病例对照研究 子宫内膜异位症的发病率 我在华盛顿州西部的一家健康维护组织注册，以验证这一假设 自然流产和人工流产可能会增加 子宫内膜异位症，考虑到可能的激素和免疫 影响。子宫内膜异位症与迟发性 将调查生育和各种避孕方法， 好.普吉特集体保健合作社的所有18-44岁注册者 声音（GHC）诊断为子宫内膜异位症的手术，和一部分 仅经体格检查或超声检查确诊者 1996年8月1日至2001年4月30日期间，将确定并邀请 参加（约750名各种族妇女）。案件将 使用计算机化记录进行选择，并由医务人员验证合格性 记录从计算机化入组文件中随机选择的对照品 将与年龄和初级保健诊所区域的病例频率相匹配。 将通过面对面访谈从病例和对照中获得数据， 人体测量;并与GHC计算机化药房联系 数据库将对受试者的生殖和 避孕史;包括自然流产和人工流产， 死产、活产、使用激素避孕药、宫内 器械和绝育手术;月经史;不孕症 病史;和其他子宫内膜异位症的危险因素。