JACKSON HEART STUDY--EXAM CENTER

杰克逊心脏研究中心--考试中心

• 批准号: 6191621
• 负责人: DANIEL W JONES
• 金额: $ 108万
• 依托单位: UNIVERSITY OF MISSISSIPPI MED CTR
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-06-01 至 2005-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6191621
• 关键词: African American; cardiovascular disorder diagnosis; cardiovascular disorder epidemiology; cardiovascular disorder prevention; clinical research; community; coronary disorder; disease /disorder etiology; geographic site; heart enlargement; heart failure; human middle age (35-64); human old age (65+); human subject; hypertension; kidney circulation disorder; longitudinal human study; minority health professional; minority institution research support; patient /disease registry; stroke

Despite encouraging declines over the past three decades, cardiovascular disease (CVD) remains the number one cause of death in the U.S. A number of risk factors for coronary heart disease (CHD) and stroke have been identified; however, relatively few population-based studies have examined CVD in a large group of African-Americans. Existing evidence indicated that death rates in Mississippi are the highest in the nation and particularly high among African-Americans. Between 1980 and 1995, the decline in CVD death rates has been the slowest among African-American men and women in Mississippi relative to other groups in the state and nation. The Jackson Heart Study (JHS) is a single-site prospective epidemiologic investigation of CVD among approximately 6,500 African-Americans ages 35 to 84, from Jackson, Mississippi metropolitan area. The primary objective of the JHS is to investigate the causes of CVD in African- Americans to learn how to best prevent this group of diseases in the future. More specific objectives include: (1) Identifying factors which influence the development and worsening of CVD in African-Americans, with an emphasis on Manifestations related to high blood pressure (such as enlargement of the left ventricle of the heart, coronary artery disease, heart failure, stroke and disorders affecting the blood vessels of the kidney). (2) Building research capabilities in minority institutions at the undergraduate and graduate level by developing partnerships between minority and majority institutions and enhancing participation of minority investigators in large-scale epidemiologic studies. (3) Attaching minority students to and preparing them for careers in public health and epidemiology. This project serves as the Coordinating Center where all data collected during the study will be managed, analysis of the data will be performed, and community involvement will be coordinated.

尽管在过去的三十年中令人鼓舞的下降，心血管疾病（CVD）仍然是美国的头号死因，冠心病（CHD）和中风的一些危险因素已经确定;然而，相对较少的基于人群的研究在一大群非洲裔美国人中检查了CVD。现有证据表明，密西西比的死亡率是全国最高的，尤其是非洲裔美国人的死亡率。1980年至1995年期间，与该州和全国的其他群体相比，密西西比的非洲裔美国男性和女性的心血管疾病死亡率下降最慢。杰克逊心脏研究（JHS）是一项在密西西比大都市区杰克逊约6,500名年龄在35至84岁的非裔美国人中进行的CVD单中心前瞻性流行病学调查。JHS的主要目标是调查非裔美国人心血管疾病的原因，以了解如何在未来最好地预防这组疾病。更具体的目标包括：（1）确定影响非裔美国人心血管疾病发展和恶化的因素，重点是与高血压有关的表现（如心脏左心室扩大、冠状动脉疾病、心力衰竭、中风和影响肾血管的疾病）。(2)通过发展少数民族和多数民族机构之间的伙伴关系，加强少数民族调查人员参与大规模流行病学研究，在本科和研究生一级建立少数民族机构的研究能力。(3)使少数民族学生参与并为他们在公共卫生和流行病学方面的职业生涯做好准备。本项目作为协调中心，将管理研究期间收集的所有数据，进行数据分析，并协调社区参与。