DOPAMINE FUNCTION AFTER PRENATAL ETHANOL EXPOSURE
产前乙醇暴露后的多巴胺功能
基本信息
- 批准号:6198578
- 负责人:
- 金额:$ 19.55万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1999
- 资助国家:美国
- 起止时间:1999-04-01 至 2004-03-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Our previous studies demonstrate that prenatal ethanol exposure produces
a persistent reduction in the electrical activity of midbrain dopamine
neurons and alters dopamine receptor sensitivity. These changes are
normalized by DA agonist administration. Midbrain DA neurotransmission
is involved in many important CNS functions including reward, motor
control attention, and locomotor activity. Therefore, prenatal ethanol
exposure-induced dopamine hypofunction may contribute to the
attention/hyperactivity problems commonly observed in children with
fetal alcohol effects, fetal alcohol syndrome (FAE/FAS). In the proposed
studies, we will use extracellular and intracellular
electrophysiological recording techniques to further characterize the
postnatal developmental process of dopamine systems that prenatal
ethanol exposure. We will study how these changes may be normalized by
dopamine agonists. We will also initiate behavioral experiments to
correlate dopamine hypofunction and attention problems. In addition, the
cellular leading to a reduction in the electrical activity of dopamine
neurons after prenatal ethanol exposure will be examined. The results of
these studies will better our understanding in the etiology of
behavioral symptoms in FAE/FAS and help us to develop more appropriate
animal models to advance the pharmacological treatment of FAE/FAS.
我们之前的研究表明,产前乙醇暴露会产生
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
ROH-YU SHEN其他文献
ROH-YU SHEN的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('ROH-YU SHEN', 18)}}的其他基金
Role of Microglia in Prenatal ethanol exposure-induced Impairment of Endocannabinoid Signaling
小胶质细胞在产前乙醇暴露引起的内源性大麻素信号传导损伤中的作用
- 批准号:
10708739 - 财政年份:2022
- 资助金额:
$ 19.55万 - 项目类别:
Role of Microglia in Prenatal ethanol exposure-induced Impairment of Endocannabinoid Signaling
小胶质细胞在产前乙醇暴露引起的内源性大麻素信号传导损伤中的作用
- 批准号:
10317305 - 财政年份:2022
- 资助金额:
$ 19.55万 - 项目类别:
Prenatal Ethanol Exposure on Executive Function
产前乙醇暴露对执行功能的影响
- 批准号:
9902268 - 财政年份:2018
- 资助金额:
$ 19.55万 - 项目类别:
Prenatal Ethanol Exposure on Executive Function
产前乙醇暴露对执行功能的影响
- 批准号:
10132947 - 财政年份:2018
- 资助金额:
$ 19.55万 - 项目类别:
Prenatal Ethanol Exposure on Executive Function
产前乙醇暴露对执行功能的影响
- 批准号:
10383150 - 财政年份:2018
- 资助金额:
$ 19.55万 - 项目类别:
Addiction Propensity After Prenatal Ethanol Exposure
产前乙醇暴露后的成瘾倾向
- 批准号:
8038926 - 财政年份:2010
- 资助金额:
$ 19.55万 - 项目类别:
Addiction Propensity After Prenatal Ethanol Exposure
产前乙醇暴露后的成瘾倾向
- 批准号:
8204430 - 财政年份:2010
- 资助金额:
$ 19.55万 - 项目类别:
Addiction Propensity After Prenatal Ethanol Exposure
产前乙醇暴露后的成瘾倾向
- 批准号:
8374130 - 财政年份:2010
- 资助金额:
$ 19.55万 - 项目类别:
Addiction Propensity After Prenatal Ethanol Exposure
产前乙醇暴露后的成瘾倾向
- 批准号:
8577118 - 财政年份:2010
- 资助金额:
$ 19.55万 - 项目类别:
DOPAMINE FUNCTION AFTER PRENATAL ETHANOL EXPOSURE
产前乙醇暴露后的多巴胺功能
- 批准号:
6371588 - 财政年份:1999
- 资助金额:
$ 19.55万 - 项目类别:
相似海外基金
Identifying the causal role of the amygdala in human approach-avoidance conflict behavior test
确定杏仁核在人类接近-回避冲突行为测试中的因果作用
- 批准号:
10516014 - 财政年份:2021
- 资助金额:
$ 19.55万 - 项目类别:
Identifying the causal role of the amygdala in human approach-avoidance conflict behavior test
确定杏仁核在人类接近-回避冲突行为测试中的因果作用
- 批准号:
10549552 - 财政年份:2021
- 资助金额:
$ 19.55万 - 项目类别:
Context Effects of Mobile Consumer Behavior: Test of Affect and Regulatory Focus Theory in Shopping and Investment Decisions
移动消费者行为的情境效应:购物和投资决策中的影响和监管焦点理论检验
- 批准号:
414986791 - 财政年份:
- 资助金额:
$ 19.55万 - 项目类别:
Research Grants