STATISTICAL ANALYSIS OF GENETIC EVENTS IN TUMORIGENESIS

肿瘤抑制基因的定位和特征分析 对癌症的预防和治疗具有深远的意义。的 这项研究的主要目标是开发统计工具， 加快寻找肿瘤抑制基因候选者。具体 本研究的目的是：发展统计显著性检验 这将有助于识别肿瘤抑制基因的候选者， 杂合性研究和缺失作图研究;提供方法 用于确定来自不同群体的等位基因丢失模式是否 患者之间存在显著差异; 用于执行这些程序的软件;以及 肿瘤中等位基因丢失过程的重要特征 进展 实现这些目标的方法将包括制定 肿瘤发生中遗传事件的模型，主要关注 等位基因丢失事件。 将进行功效研究， 科学家们确定样本大小，以实现各种水平的 确定肿瘤抑制基因的候选者。

The localization and characterization of tumor suppressor genes has profound implications for prevention and treatment of cancer. The primary goal of this research is to develop statistical tools to expedite the search for tumor suppressor gene candidates. The specific aims of this research are: to develop statistical significance tests that will help identify tumor suppressor gene candidates from loss of heterozygosity studies and deletion mapping studies; to provide methods for determining whether allelic loss patterns from different groups of patients are significantly different; to produce publicly available software for implementing these procedures; and to estimate biologically important characteristics of the allelic loss process in neoplastic progression. The methods for achieving these aims will involve the formulation of models for genetic events in tumorigenesis, focusing primarily on allelic loss events. Power studies will be performed which will allow scientists to determine the sample sizes to achieve various levels of certainty in the identification of tumor suppressor gene candidates.