课题基金 / 基金详情

LACTATION INDUCED REDUCTION IN BREAST CANCER RISK

LACTATION INDUCED REDUCTION IN BREAST CANCER RISK
哺乳期降低乳腺癌风险
批准号：
2895704
负责人：
DAVID KIANG
金额：
$19.83万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
1996
资助国家：
美国
项目状态：
已结题
起止时间：
1996-09-17 至 2000-12-31
来源：
https://reporter.nih.gov/project-details/2895704
关键词：
age at pregnancy breast neoplasms cancer risk cell cell interaction chemical carcinogen chorionic gonadotropin female gap junctions hormone regulation /control mechanism laboratory rat lactation mammary epithelium molecular oncology oncogenes tissue /cell culture tumor suppressor genes

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中文摘要
翻译
描述：生命早期的怀孕和哺乳与a有关
英文摘要
DESCRIPTION: Pregnancy and lactation early in life are associated with a reduced risk of human breast cancer, while pseudopregnancy induced by human chorionic gonadotropin (hCG) has a protective effect against mammary tumorigenesis in rats. The applicant hypothesizes that, by an enhanced gap junction intercellular communication during lactation, the normal mammary epithelial cells can effectively exert influence on a few transformed or premalignant cells. In this application the applicant proposes [Aim 1] that enhanced cell-cell communication induced by hCG modulates genetic alterations in rat mammary glands exposed to NMU; and [Aim II] that enhanced cell-cell communication modulates the genetic alterations in MCF-10 cells and comma-ID cells. In Aim III, he will investigate the transcriptional regulation of the human Cx26 gene by lactogenic hormones or other modulation agents.
期刊论文(6)
专著(0)
科研奖励(0)
会议论文
Differential up-regulation of gap junction connexin 26 gene in mammary and uterine tissues: the role of Sp transcription factors.
乳腺和子宫组织中间隙连接连接蛋白 26 基因的差异上调：Sp 转录因子的作用。
DOI： 10.1210/mend.12.12.0208
发表时间： 1998
期刊： Molecular endocrinology (Baltimore, Md.)
影响因子： --
作者： [Tu,ZJ, Kollander,R, Kiang,DT]
通讯作者： Kiang,DT
Modulation of the connexin26 tumor suppressor gene expression through methylation in human mammary epithelial cell lines.
DOI： --
发表时间： 2000
期刊： Anticancer research
影响因子： 2
作者： [R. Singal;Z. Tu;J. Vanwert;G. Ginder;D. Kiang]
通讯作者： R. Singal;Z. Tu;J. Vanwert;G. Ginder;D. Kiang
Direct modulation of tumor suppressor connexin 26 gene by human chorionic gonadotropin in rat mammary glands.
人绒毛膜促性腺激素对大鼠乳腺肿瘤抑制连接蛋白 26 基因的直接调节。
DOI： --
发表时间： 1998
期刊： Cancer research
影响因子： 11.2
作者： [You,S, Tu,ZJ, Kiang,DT]
通讯作者： Kiang,DT
Development, implementation and long-term maintenance of an ISO accredited progra
Development, implementation and long-term maintenance of an ISO accredited progra
Development, implementation and long-term maintenance of an ISO accredited progra
ASTROVIRUS NONSTRUCTURAL PROTEINS
  • 批准号：
    6176446
  • 项目类别：
  • 资助金额：
    $4.09万
  • 财政年份：
    2000
  • 负责人：
    DAVID KIANG
  • 依托单位：
    STANFORD UNIVERSITY
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