LACTATION INDUCED REDUCTION IN BREAST CANCER RISK

描述：生命早期的妊娠和哺乳与 降低人类乳腺癌的风险，而人类乳腺癌诱导的假孕 绒毛膜促性腺激素（hCG）对乳腺癌有保护作用。 大鼠的肿瘤发生。 申请人假设，通过增强的间隙， 哺乳期细胞间连接通讯，正常乳腺 上皮细胞可以有效地对一些转化的或 癌前细胞 在本申请中，申请人提出[目标1]， 人绒毛膜促性腺激素诱导的增强的细胞间通讯调节遗传 暴露于NMU的大鼠乳腺的变化;以及[目的II]， 细胞间通讯调节MCF-10细胞的遗传改变 和逗号ID单元。 在Aim III中，他将研究转录 通过催乳激素或其它调节对人Cx 26基因的调节 剂.

DESCRIPTION: Pregnancy and lactation early in life are associated with a reduced risk of human breast cancer, while pseudopregnancy induced by human chorionic gonadotropin (hCG) has a protective effect against mammary tumorigenesis in rats. The applicant hypothesizes that, by an enhanced gap junction intercellular communication during lactation, the normal mammary epithelial cells can effectively exert influence on a few transformed or premalignant cells. In this application the applicant proposes [Aim 1] that enhanced cell-cell communication induced by hCG modulates genetic alterations in rat mammary glands exposed to NMU; and [Aim II] that enhanced cell-cell communication modulates the genetic alterations in MCF-10 cells and comma-ID cells. In Aim III, he will investigate the transcriptional regulation of the human Cx26 gene by lactogenic hormones or other modulation agents.