LACTATION INDUCED REDUCTION IN BREAST CANCER RISK

哺乳期降低乳腺癌风险

• 批准号: 2895704
• 负责人: DAVID KIANG
• 金额: $ 19.83万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-17 至 2000-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2895704
• 关键词: age at pregnancy; breast neoplasms; cancer risk; cell cell interaction; chemical carcinogen; chorionic gonadotropin; female; gap junctions; hormone regulation /control mechanism; laboratory rat; lactation; mammary epithelium; molecular oncology; oncogenes; tissue /cell culture; tumor suppressor genes

DESCRIPTION: Pregnancy and lactation early in life are associated with a reduced risk of human breast cancer, while pseudopregnancy induced by human chorionic gonadotropin (hCG) has a protective effect against mammary tumorigenesis in rats. The applicant hypothesizes that, by an enhanced gap junction intercellular communication during lactation, the normal mammary epithelial cells can effectively exert influence on a few transformed or premalignant cells. In this application the applicant proposes [Aim 1] that enhanced cell-cell communication induced by hCG modulates genetic alterations in rat mammary glands exposed to NMU; and [Aim II] that enhanced cell-cell communication modulates the genetic alterations in MCF-10 cells and comma-ID cells. In Aim III, he will investigate the transcriptional regulation of the human Cx26 gene by lactogenic hormones or other modulation agents.

描述：生命早期的怀孕和哺乳与 降低人类乳腺癌的风险，而人类诱导的假孕 绒毛膜促性腺激素(HCG)对乳腺有保护作用 大鼠的肿瘤发生。申请人假设，通过扩大差距， 正常乳腺在哺乳期的连接细胞间通讯 上皮细胞可以有效地对少数转化或 癌前细胞。在本申请书中，申请人提议[目标1] 人绒毛膜促性腺激素增强细胞间通讯调节基因 暴露于NMU的大鼠乳腺的变化；[Aim II]增强 细胞间通讯调节MCF-10细胞的遗传改变 和逗号ID单元格。在AIM III中，他将研究转录 催乳激素或其他调节对人类Cx26基因的调节 探员们。

项目成果

Differential up-regulation of gap junction connexin 26 gene in mammary and uterine tissues: the role of Sp transcription factors.

乳腺和子宫组织中间隙连接连接蛋白 26 基因的差异上调：Sp 转录因子的作用。

• DOI: 10.1210/mend.12.12.0208
• 发表时间: 1998
• 期刊: Molecular endocrinology (Baltimore, Md.)
• 作者: Tu,ZJ;Kollander,R;Kiang,DT
• 通讯作者: Kiang,DT

Modulation of the connexin26 tumor suppressor gene expression through methylation in human mammary epithelial cell lines.

• 发表时间: 2000
• 期刊: Anticancer research
• 影响因子: 2
• 作者: R. Singal;Z. Tu;J. Vanwert;G. Ginder;D. Kiang

Direct modulation of tumor suppressor connexin 26 gene by human chorionic gonadotropin in rat mammary glands.

人绒毛膜促性腺激素对大鼠乳腺肿瘤抑制连接蛋白 26 基因的直接调节。

• 发表时间: 1998
• 期刊: Cancer research
• 影响因子: 11.2
• 作者: You,S;Tu,ZJ;Kiang,DT
• 通讯作者: Kiang,DT