ADHERENCE TO HIV THERAPIES IN DRUG USERS

描述：(申请者摘要)吸毒者坚持接受艾滋病毒治疗 在新奥尔良 这项提案旨在探索遵守新的艾滋病毒治疗方案。 在有吸毒史的人群中，到HIV门诊就诊 路易斯安那州医学中心(HOP)在新奥尔良的项目。坚守 对慢性药物治疗是改变 这些新疗法的有效性。新型联合抗逆转录病毒药物 治疗方法有望将艾滋病毒转变为一种慢性病。然而， 抗逆转录病毒药物治疗方案的复杂性。副作用。和不断变化的 艾滋病患者的人口可能会增加不遵守的可能性 使用这些长期使用的药物。不幸的是，即使是相对温和的 不坚持某些联合治疗方案。尤其是那些 其中包括一种蛋白酶抑制剂，可能会导致病毒耐药性，逆转 HIV-I病的进展与多种抗逆转录病毒药物的无效 毒品。同样，对于这一点，也不存在全面的遵守模式 或任何人口。这项由杜兰大学于#年提出的建议 与路易斯安那州立大学和有远见的女性合作 以非裔美国人为基础的社区组织，有与i 注射吸毒者。是探索社会、文化和个人的独特努力 导致遵守或不遵守的因素。该项目将： 1)分析人口统计学上的市中心吸毒人群 类似于即将到来的一代艾滋病患者：2)混合使用 证实依从性的方法。包括对比临床和我 处方索赔数据和自我报告；3)涉及 探索遵守问题；以及4)探索社交网络的影响 解释依从性的理论和社会网络分析方法 行为。

DESCRIPTION: (Applicant's Abstract) Adherence to HIV Therapy in Drug Users in New Orleans This proposal is designed to explore adherence to new HIV treatment regimens in a population with a history of drug use attending the HIV Outpatient Program of the Medical Center of Louisiana (HOP) in New Orleans. Adherence to chronic drug therapy is an important factor in modifying the effectiveness of these new treatments. New combination antiretroviral drug therapies promise to convert HIV into a chronic disease. Yet, the complexity of antiretroviral drug regimens. side effects. and the changing population of AIDS patients may increase the likelihood of non-adherence with these chronically-used drugs. Unfortunately, even relatively modest non-adherence with some of the combination regimens. particularly those which include a protease inhibitor, may lead to viral resistance, reversed progression of HIV I disease and ineffectiveness of multiple antiretroviral drugs. Equally, a comprehensive model of adherence does not exist for this or any population. This proposal, conducted by Tulane University in collaboration with Louisiana State University and Women with a Vision, an African-American community based organization with a history of work with I IDUs. is a unique effort to explore the social, cultural and personal factors which contribute to adherence or non-adherence. This project will: 1) analyze an inner-city drug-using population that is demographically similar to the I upcoming generation of AIDS patients: 2) use a mix of methods to corroborate adherence. including comparing clinic and i prescription claims data, and self-report; 3) involves ethnography in exploring adherence issues; and 4) explores social network influence theories and social network analysis methods to account for adherence behaviors.