FAMILIAL STUDY OF SEVERE PHONOLOGY DISORDERS
FAMILIAL STUDY OF SEVERE PHONOLOGY DISORDERS
批准号:
2763462
负责人:
BARBARA A LEWIS
金额:
$34.95万
依托单位国家:
美国
项目类别:
财政年份:
1999
资助国家:
美国
项目状态:
已结题
起止时间:
1999-01-01 至 2003-12-31
关键词:
adolescence (12-20) apraxias behavioral /social science research tag behavioral genetics clinical research developmental genetics family genetics gender difference genetic markers human subject language development language disorders linkage disequilibriums linkage mapping longitudinal human study middle childhood (6-11) phenotype phonology preschool child (1-5) reading siblings speech speech disorders spelling statistics /biometry
中文摘要
该项目将研究的家庭和遗传基础,
发育性语音障碍,最普遍的群体,
儿童沟通障碍。 行为和分子遗传学
技术将用于区分临床基础的表型,
发育性音位学障碍,包括发育中的音位学障碍
与其他语言共病的孤立,语音障碍
和发育性言语失用症。 一大群同胞
对,N=500,通过患有语音障碍的先证者确定,
将在语音,表达和接受的措施进行检查
语言、演讲和阅读。 数据分析,包括隔离
分析,将检查家庭相似性,兄弟姐妹的相关性,
遗传性 基于遗传连锁分析的无模型方法
在兄弟姐妹对将被用来评估候选基因,
与语音处理能力有关,
阅读。 表型和传播方式的性别差异
将检查语音障碍。纵向随访
有学龄前语音障碍史的人将提供
关于青少年言语、语言、阅读、拼写和
写作能力。 该项目的总体目标是改善
了解遗传基础,行为表型和发育
语音障碍的后果。
英文摘要
This project will examine the familial and genetic basis of
developmental phonology disorders, the most prevalent group of
communication disorders in children. Behavioral and molecular genetic
techniques will be used to differentiate clinically based phenotypes of
developmental phonology disorders, including phonology disorders in
isolation, phonology disorders that are comorbid with other language
disorders, and developmental apraxia of speech. A large cohort of sib
pairs, N=500, ascertained through a proband with a phonology disorder,
will be examined on measures of phonology, expressive and receptive
language, speech, and reading. Data analysis, including segregation
analyses, will examine family resemblance, sibling correlations, and
heritability. Model-free approaches to genetic linkage analysis based
upon sibling pairs will be used to evaluate candidate genes that have
been associated with phonological processing abilities in studies of
reading. Gender differences in phenotypes and modes of transmission of
phonology disorders will be examined. Longitudinal follow-up of
individuals with histories of preschool phonology disorders will provide
data on adolescent outcomes for speech, language, reading, spelling and
writing abilities. The overall aim of the project is to improve
understanding of genetic basis, behavioral phenotypes, and developmental
outcomes of phonology disorders.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
FAMILIALITY OF SEVERE PHONOLOGY DISORDERS: READING DISORDERS & SEGREGAT ANALYSIS
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批准号:6491957
-
项目类别:
-
资助金额:$29.46万
-
财政年份:2001
-
负责人:BARBARA A LEWIS
-
依托单位:
FAMILIAL STUDY OF SEVERE PHONOLOGY DISORDERS
-
批准号:6137855
-
项目类别:
-
资助金额:$33.63万
-
财政年份:1999
-
负责人:BARBARA A LEWIS
-
依托单位:
Familial Study of Severe Phonology Disorders
-
批准号:6914428
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项目类别:
-
资助金额:$54.14万
-
财政年份:1999
-
负责人:BARBARA A LEWIS
-
依托单位:
A Familial Study of Severe Phonology Disorders
-
批准号:7580668
-
项目类别:
-
资助金额:$63.13万
-
财政年份:1999
-
负责人:BARBARA A LEWIS
-
依托单位:
A Familial Study of Severe Phonology Disorders
-
批准号:8119631
-
项目类别:
-
资助金额:$63.12万
-
财政年份:1999
-
负责人:BARBARA A LEWIS
-
依托单位:
FAMILIALITY OF SEVERE PHONOLOGY DISORDERS: READING DISORDERS & SEGREGAT ANALYSIS
-
批准号:6206098
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项目类别:
-
资助金额:$0.0万
-
财政年份:1999
-
负责人:BARBARA A LEWIS
-
依托单位:
FAMILIAL STUDY OF SEVERE PHONOLOGY DISORDERS
-
批准号:6342316
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项目类别:
-
资助金额:$42.3万
-
财政年份:1999
-
负责人:BARBARA A LEWIS
-
依托单位:
Biological and Behavioral Markers of Persistent Speech Sound Disorders
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批准号:8816198
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项目类别:
-
资助金额:$63.26万
-
财政年份:1999
-
负责人:BARBARA A LEWIS
-
依托单位:
Biological and Behavioral Markers of Persistent Speech Sound Disorders
-
批准号:9316578
-
项目类别:
-
资助金额:$62.1万
-
财政年份:1999
-
负责人:BARBARA A LEWIS
-
依托单位:
A Familial Study of Severe Phonology Disorders
-
批准号:7900534
-
项目类别:
-
资助金额:$63.76万
-
财政年份:1999
-
负责人:BARBARA A LEWIS
-
依托单位:
A Familial Study of Severe Phonology Disorders
-
批准号:7689762
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项目类别:
-
资助金额:$62.88万
-
财政年份:1999
-
负责人:BARBARA A LEWIS
-
依托单位:
A Familial Study of Severe Phonology Disorders
-
批准号:8302371
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项目类别:
-
资助金额:$60.67万
-
财政年份:1999
-
负责人:BARBARA A LEWIS
-
依托单位:
FAMILIAL STUDY OF SEVERE PHONOLOGY DISORDERS
-
批准号:6626851
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项目类别:
-
资助金额:$44.33万
-
财政年份:1999
-
负责人:BARBARA A LEWIS
-
依托单位:
Familial Study of Severe Phonology Disorders
-
批准号:6823461
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项目类别:
-
资助金额:$55.23万
-
财政年份:1999
-
负责人:BARBARA A LEWIS
-
依托单位:
FAMILIAL STUDY OF SEVERE PHONOLOGY DISORDERS
-
批准号:6489523
-
项目类别:
-
资助金额:$43.34万
-
财政年份:1999
-
负责人:BARBARA A LEWIS
-
依托单位:
Familial Study of Severe Phonology Disorders
-
批准号:7084499
-
项目类别:
-
资助金额:$54.45万
-
财政年份:1999
-
负责人:BARBARA A LEWIS
-
依托单位:
FAMILIALITY OF SEVERE PHONOLOGY DISORDERS
-
批准号:6121779
-
项目类别:
-
资助金额:$0.7万
-
财政年份:1998
-
负责人:BARBARA A LEWIS
-
依托单位:
FAMILIALITY OF SEVERE PHONOLOGY DISORDERS
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批准号:6252889
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项目类别:
-
资助金额:$1.42万
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财政年份:1997
-
负责人:BARBARA A LEWIS
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依托单位:
FAMILIAL STUDY OF SEVERE PHONOLOGY DISORDERS
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批准号:3461612
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项目类别:
-
资助金额:$10.8万
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财政年份:1988
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负责人:BARBARA A LEWIS
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依托单位:
FAMILIAL STUDY OF SEVERE PHONOLOGY DISORDERS
-
批准号:3461610
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项目类别:
-
资助金额:$7.5万
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财政年份:1988
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负责人:BARBARA A LEWIS
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依托单位:
海外基金