HIV 诱导的免疫细胞归巢和反应-猫眼课题宝

HIV 诱导的免疫细胞归巢和反应

批准号：

2887946

负责人：

SUJATHA IYENGAR

金额：

$24.3万

依托单位：

JOHNS HOPKINS UNIVERSITY

依托单位国家：

美国

项目类别：

财政年份：

1998

资助国家：

美国

项目状态：

已结题

起止时间：

1998-09-30 至 2001-09-29

来源：

https://reporter.nih.gov/project-details/2887946

关键词：

HIV envelope protein gp120 HIV infections T lymphocyte cellular immunity chemokine chemotaxis clinical research cytokine receptors human subject leukocyte activation /transformation longitudinal human study lymph nodes neutrophil positron emission tomography receptor binding receptor expression virion virus infection mechanism

项目摘要

项目成果

SUJATHA IYENGAR的其他基金

相似基金

相关文献

中文摘要

翻译

点击翻译按钮获取中文摘要

英文摘要

DESCRIPTION: The goals of this proposal are to understand in more detail the trafficking of lymphocytes in HIV infection. One aim focuses on patterns of lymph node (LN) involvement with HIV during the disease course using PET scanning to identify LN sites of activation (a presumed surrogate for sites of infection). This study will longitudinally follow newly infected and chronically subjects begun on HAART for about 18 mo and will translate to humans previous primate studies. The second aim moves to the cellular level to study the chemotactic properties of CXCR4 and CCR5 tropic HIV gp120 or whole virions on different subsets of resting or activated T lymphocytes and monocytes.

期刊论文(0)

专著(0)

科研奖励(0)

会议论文