MODERATE ALCOHOL AND THE HEMOSTATIC SYSTEM

描述：人们对酒精对血小板影响的兴趣与日俱增。 因为有报道称，适量饮酒可降低心血管死亡率。 饮酒可能会影响疾病的发病率，包括 血小板，包括中风和(F)心肌梗塞。尽管很受欢迎 尽管如此，关于血小板功能的研究结果好坏参半。一般来说， 酒精会抑制血小板功能，但其他研究表明 刺激，尤指激活级联反应中的早期事件。在.期间 酗酒者戒断，血小板经历反弹，成为 太敏感了。因此，出现了一幅复杂而不完整的图景。特别是， 关于适度饮酒如何影响血小板的流行病学研究很少 在正常人身上已经进行了反应，事实上，关键是 在这样的研究能够有效之前，仍然需要初步的数据 建议。我们的假设是适量饮酒会降低血小板 活动，潜在地预防血栓相关的心血管疾病 意外事故。长期目标是进行有控制的 饮酒行为对血小板影响的流行病学研究 正常男性和女性的功能。本申请的目标是 在履行此类任务之前完成必要的初步研究 流行病学研究。我们的具体目标是：1)在正常人身上建立 和女性，饮酒和饮酒之间的剂量-反应关系 抑制血小板功能，包括激动剂的特异性；2)评估 血小板饮酒反应的时间依赖性；3) 确定最合适的制剂(全血/富含血小板 血浆/洗涤的血小板)，用于测量饮酒的影响；4) 确定酒精对健康影响的最合适的机制研究 止血系统，用于以后的流行病学研究， 包括对血栓素产生、环核苷酸和 纤溶酶原激活系统。这些研究将在临床上解决 相关的方式，我们对酒精消费的了解不足 改变与血小板有关的疾病状态的发生率，并为 为这一领域有意义的流行病学调查奠定基础。

DESCRIPTION: Interest in effects of alcohol on blood platelets has grown due to reports that moderate drinking reduces cardiovascular mortality. Alcohol consumption may affect the incidence of disorders involving platelets, including stroke an(f myocardial infarction. Despite the popular view, studies on platelet function have had mixed results. Generally, platelet function is inhibited by alcohol, but other studies show stimulation, particularly of early events in the activation cascade. During withdrawal in alcoholics, platelets undergo a rebound, becoming hypersensitive. Thus a complex, incomplete picture emerges. In particular, few epidemiological studies of how moderate drinking affects platelet reactivity in normal individuals have been performed, and in fact, key preliminary data are still needed before such studies can be effectively proposed. Our hypothesis is that moderate drinking will reduce platelet activity, potentially protecting against thrombosis-related cardiovascular accidents. The long range goal is to conduct a well-controlled epidemiological study of the effects of drinking behavior on platelet function in normal men and women. The goals of the present application are to complete preliminary studies necessary before the performance of such an epidemiological study. Our specific aims are to 1) establish, in normal men and women, the dose-response relationship between alcohol consumption and inhibition of platelet function, including agonist specificity; 2) evaluate time-dependency of responses of platelets to alcohol consumption; 3) determine the most appropriate preparation (whole blood/platelet rich plasma/washed platelets) for measurement of effects of drinking; 4) determine the best-suited mechanistic studies for alcohol's effects on the hemostatic system, for application to later epidemiological studies, including effects on thromboxane production, cyclic nucleotides, and the plasminogen activator system. These studies will address, in a clinically relevant manner, a deficit in our knowledge of how alcohol consumption alters incidence of disease states involving platelets, and lay the groundwork for meaningful epidemiological investigations in this area.