GASTROINTESTINAL AUTONOMIC DYSFUNCTION
胃肠道自主功能障碍
基本信息
- 批准号:6082829
- 负责人:
- 金额:$ 3.49万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1998
- 资助国家:美国
- 起止时间:1998-12-01 至 1999-11-30
- 项目状态:已结题
- 来源:
- 关键词:biological signal transduction calcium channel calcium flux calcium indicator calcium metabolism calmodulin dependent protein kinase cell proliferation developmental neurobiology enzyme activity gap junctions gastrointestinal system gene expression glia guinea pigs immunocytochemistry inositol phosphates insulinlike growth factor microinjections mitogen activated protein kinase myenteric plexus neurogenetics neurons neurotransmitter metabolism neurotrophic factors regulatory gene tissue /cell culture
项目摘要
DESCRIPTION: (Adapted from the applicant's abstract) Studies performed in
the past decade indicate that the intrinsic nervous system of the alimentary
tract regulates nearly every aspect of digestion. Emerging evidence also
indicates that the enteric nervous system may be vulnerable to injury from a
variety of causes. In most instances, the neuropathological changes that
underlie human disorders have not been clearly established, and little is
known of the mechanisms involved in their evolution. These deficiencies are
reflected in the currently empiric, and often ineffective, treatment of
human enteric neuropathic disease. The research program supported by this
grant has focused upon this lack of information. Using novel in vitro
approaches, studies have examined enteric neuronal growth, functional
development, and neurotransmitter release. Technical refinements have
permitted the examination of small amounts of tissue, to the level of
individual cells. Physiologic correlations have been possible. The current
proposal extends these investigations. In the current proposal the
investigators hypothesize that: 1) enteric neurons respond to excitatory
neurotransmitters by increasing intracellular calcium; 2) glial cells also
respond to neuroligands by modulation of intracellular calcium; 3)
intercellular signaling occurs both by release of neurotransmitter molecules
and by direct cell-to-cell contact; 4) signaling pathways in enteric neurons
and glia are linked to distinct systems of cellular activation and
functional response. This proposal seeks to address, at a fundamental
level, the deficiency of information about the enteric nervous system.
描述:(改编自申请人的摘要)在
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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MICHAEL W. MULHOLLAND其他文献
MICHAEL W. MULHOLLAND的其他文献
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{{ truncateString('MICHAEL W. MULHOLLAND', 18)}}的其他基金
Gastric X/A Like Cells in Health and Diseases
健康和疾病中的胃 X/A 样细胞
- 批准号:
10183235 - 财政年份:2018
- 资助金额:
$ 3.49万 - 项目类别:
Gastric X/A Like Cells in Health and Diseases
健康和疾病中的胃 X/A 样细胞
- 批准号:
9438610 - 财政年份:2018
- 资助金额:
$ 3.49万 - 项目类别:
Gastric X/A Like Cells in Health and Diseases
健康和疾病中的胃 X/A 样细胞
- 批准号:
10399643 - 财政年份:2018
- 资助金额:
$ 3.49万 - 项目类别:
R-spondin1-LGR4 Signaling and Ischemia/Reperfusion Injury in Steatotic Liver
脂肪肝中的 R-spondin1-LGR4 信号转导和缺血/再灌注损伤
- 批准号:
9896813 - 财政年份:2017
- 资助金额:
$ 3.49万 - 项目类别:
R-spondin1-LGR4 Signaling and Ischemia/Reperfusion Injury in Steatotic Liver
脂肪肝中的 R-spondin1-LGR4 信号转导和缺血/再灌注损伤
- 批准号:
9303031 - 财政年份:2017
- 资助金额:
$ 3.49万 - 项目类别:
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