GASTROINTESTINAL AUTONOMIC DYSFUNCTION

胃肠道自主功能障碍

基本信息

项目摘要

DESCRIPTION: (Adapted from the applicant's abstract) Studies performed in the past decade indicate that the intrinsic nervous system of the alimentary tract regulates nearly every aspect of digestion. Emerging evidence also indicates that the enteric nervous system may be vulnerable to injury from a variety of causes. In most instances, the neuropathological changes that underlie human disorders have not been clearly established, and little is known of the mechanisms involved in their evolution. These deficiencies are reflected in the currently empiric, and often ineffective, treatment of human enteric neuropathic disease. The research program supported by this grant has focused upon this lack of information. Using novel in vitro approaches, studies have examined enteric neuronal growth, functional development, and neurotransmitter release. Technical refinements have permitted the examination of small amounts of tissue, to the level of individual cells. Physiologic correlations have been possible. The current proposal extends these investigations. In the current proposal the investigators hypothesize that: 1) enteric neurons respond to excitatory neurotransmitters by increasing intracellular calcium; 2) glial cells also respond to neuroligands by modulation of intracellular calcium; 3) intercellular signaling occurs both by release of neurotransmitter molecules and by direct cell-to-cell contact; 4) signaling pathways in enteric neurons and glia are linked to distinct systems of cellular activation and functional response. This proposal seeks to address, at a fundamental level, the deficiency of information about the enteric nervous system.
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项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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MICHAEL W. MULHOLLAND其他文献

MICHAEL W. MULHOLLAND的其他文献

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{{ truncateString('MICHAEL W. MULHOLLAND', 18)}}的其他基金

Gastric X/A Like Cells in Health and Diseases
健康和疾病中的胃 X/A 样细胞
  • 批准号:
    10183235
  • 财政年份:
    2018
  • 资助金额:
    $ 3.49万
  • 项目类别:
Gastric X/A Like Cells in Health and Diseases
健康和疾病中的胃 X/A 样细胞
  • 批准号:
    9438610
  • 财政年份:
    2018
  • 资助金额:
    $ 3.49万
  • 项目类别:
Gastric X/A Like Cells in Health and Diseases
健康和疾病中的胃 X/A 样细胞
  • 批准号:
    10399643
  • 财政年份:
    2018
  • 资助金额:
    $ 3.49万
  • 项目类别:
R-spondin1-LGR4 Signaling and Ischemia/Reperfusion Injury in Steatotic Liver
脂肪肝中的 R-spondin1-LGR4 信号转导和缺血/再灌注损伤
  • 批准号:
    9896813
  • 财政年份:
    2017
  • 资助金额:
    $ 3.49万
  • 项目类别:
R-spondin1-LGR4 Signaling and Ischemia/Reperfusion Injury in Steatotic Liver
脂肪肝中的 R-spondin1-LGR4 信号转导和缺血/再灌注损伤
  • 批准号:
    9303031
  • 财政年份:
    2017
  • 资助金额:
    $ 3.49万
  • 项目类别:
Obesity is a Surgical Problem
肥胖是一个外科问题
  • 批准号:
    7058226
  • 财政年份:
    1998
  • 资助金额:
    $ 3.49万
  • 项目类别:
Obesity is a Surgical Problem
肥胖是一个外科问题
  • 批准号:
    8066467
  • 财政年份:
    1998
  • 资助金额:
    $ 3.49万
  • 项目类别:
Obesity is a Surgical Problem
肥胖是一个外科问题
  • 批准号:
    7646684
  • 财政年份:
    1998
  • 资助金额:
    $ 3.49万
  • 项目类别:
Obesity is a Surgical Problem
肥胖是一个外科问题
  • 批准号:
    6706341
  • 财政年份:
    1998
  • 资助金额:
    $ 3.49万
  • 项目类别:
Obesity is a Surgical Problem
肥胖是一个外科问题
  • 批准号:
    6875048
  • 财政年份:
    1998
  • 资助金额:
    $ 3.49万
  • 项目类别:

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    2200474
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用于治疗慢性疼痛的一流选择性 T 型钙通道阻滞剂的设计和临床前开发
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