IDENT OF H PYLORI VIRUL FACTORS IN ETHNIC POPULATIONS

描述(取自应用程序) 幽门螺杆菌(Hp)是一种常见的世界性感染；现在已知它是 病因与胃炎、消化性溃疡、胃病有关 腺癌和原发性胃淋巴瘤。幽门螺杆菌感染的结局 不同民族之间的差异是不同的。例如，在美国， 虽然Hp感染在所有种族中都被检测到，但胃癌是 在西班牙裔、黑人、越南人、韩国人、日本人和 美国印第安人，与白人人口相比。可能因素(S) 造成这些差异的原因包括宿主或 环境因素(例如，在饮食中)或在毒力方面的差异 在一个民族中流行的常见的幽门螺杆菌菌株(S)。虽然环保 或者宿主因素可能是重要的，毒力的差异是一种 很有可能是因为在许多其他细菌疾病中 一种疾病的发生可能与特定的毒力因素直接相关。数据 来自多个实验室的研究表明，不同组的Hp菌株 是存在的。可能的毒力标记，如cagA和VacA基因及其 蛋白质产品，也已被鉴定，它们可能是不同的 在不同的幽门螺杆菌相关性胃肠道疾病中存在或表达。我们的 初步假设幽门螺杆菌感染的不同疾病表现 在不同的民族中体现了异质性和 不同毒力因子在幽门螺杆菌优势株S中的表达 在少数民族中流传。这项研究的具体目标是： 以确定是否存在Hp毒力因子，包括基因 幽门螺杆菌分离株在不同种族中的表型变异 在美国，可与胃炎的严重程度、程度或模式相关。 我们还计划使用DNA指纹分析方法，REP-PCR来评估 幽门螺杆菌不同种族内和种族间的遗传相似性 组。这项研究还将确定患病率的差异 而特定候选毒力因子的异质性可能是 导致疾病程度和严重程度不同的潜在机制 新疆不同民族人群幽门螺杆菌相关性胃损害与疾病 美国。

DESCRIPTION (taken from the application) Helicobacter pylori (Hp) is a common worldwide infection; it is now known to be etiologically related to gastritis, peptic ulcer disease, gastric adenocarcinoma, and primary gastric lymphoma. The outcome of Hp infection differs among different ethnic groups. For example, in the United States although Hp infection is detected in all ethnic groups, gastric cancer is more common in Hispanics, Blacks, Vietnamese, Koreans, Japanese, and American Indians, compared to the white population. Possible factor(s) responsible for these differences include subtle distinctions in host or environmental factors (e.g., in diet) or differences in virulence in the common Hp strain(s) circulating within an ethnic group. While environmental or host factors are likely to be important, differences in virulence is a likely possibility because in many other bacterial diseases the expression of a disease can be directly related to specific virulence factors. Data from a number of laboratories suggest that different groups of Hp strains exist. Putative virulence markers, such as cagA and vacA genes and their protein products, have also been identified and they may be differentially present or expressed in different Hp-related gastrointestinal diseases. Our primary hypothesis is that different disease manifestations of Hp infection in different ethnic groups is a reflection of the heterogeneity and expression of different virulence factors in the predominant Hp strain(s) circulating in the ethnic group. The specific objectives of this study are: To determine whether the presence of Hp virulence factors, including genetic and/or phenotypic variations in Hp isolates within different ethnic groups in the US, can be correlated with severity, extent, or pattern of gastritis. We also plan to use the DNA fingerprinting method, REP-PCR, to assess genetic similarity among Hp isolates within and between different ethnic groups. This study will also determine whether differences in prevalence and heterogeneity of specific candidate virulence factors may be the underlying mechanism leading to differences in the extent and severity of Hp-related gastric damage and diseases in different ethnic groups in the United States.