CALCIUM SIGNALING

寻求资金来部分支持戈登钙信号研究会议，该会议将于1999年8月8-13日在新罕布什尔州亨尼克的新英格兰学院举行。会议为钙信号传导领域的思想和信息交流提供了一个独特的多学科论坛。由于钙信号是所有真核生物（从酵母到哺乳动物细胞）共同的细胞控制的基本手段，因此，通过刺激使用丰富多样的不同生物和细胞系统的工人交换细胞调节的基本信息，会议获得了特别的力量。主要目标是促进新老调查员之间的成功互动。优先选择和提供资金，支持青年科学家（学生和博士后学员）、女科学家和代表性不足的少数民族科学家。会议将包括8个会议，包括研究报告和广泛的讨论，每个会议由该领域的杰出成员领导，他们在最大限度地提高互动交流方面具有经验。此外，钙信号领域的先驱，MEHS的James W. Putney, Jr.博士也将发表主题演讲。此外，还将有两次海报会议，从海报演讲者中选出的年轻科学家有机会在主要会议上口头介绍他们的工作。每个计划的会议将重点关注钙信号传导的及时和核心方面，包括细胞内IP3受体的分子性质和调节，钙信号传导事件的时空控制，线粒体在钙信号传导中的作用以及作为细胞损伤和凋亡的介质，脑和外周组织中钙信号传导的靶点，以及钙和其他细胞内离子研究方法的最新进展。参与者包括成熟和成功的年轻研究人员，他们代表了一系列细胞系统和不同的技术，从分子生物学分析和钙信号机制的操作到复杂和开创性的微成像技术，以观察钙信号的产生和传播。参与者的基础学科包括生物化学、生理学、细胞生物学、分子生物学、生物物理学、病理学和药理学；然而，所有人都对理解细胞中钙信号事件的机制和意义感兴趣。本次会议将讨论的主题对我们理解一些健康问题非常重要，包括与环境健康、癌症生物学、囊性纤维化、糖尿病、神经退行性疾病和衰老等有关的问题。

Funds are sought to cover partial support of the Gordon Research Conference on Calcium Signaling, to be held at New England College, Henniker, NH, August 8-13, 1999. The meeting provides a unique multidisciplinary forum for interchange of ideas and information in the field of calcium signaling. Since calcium signaling is a fundamental means of cellular control common to all eukaryotic organisms, from yeast to mammalian cells, the meeting derives particular strength by stimulating the interchange of basic information on cell regulation from workers using a rich variety of different organisms and cellular systems. The primary objective is to facilitate successful interactions between new and established investigators. Highest priority will be given to the selection and provision of funds to support junior scientists (student and postdoctoral trainees), women scientists, and under-represented minority scientists. The conference will include 8 sessions with research presentations and extensive discussion, each lead by a prominent member of the field with experience in maximizing interactive exchange. There will also be a keynote address given by Dr. James W. Putney, Jr. of MEHS, a pioneer in the calcium signaling field. In addition, there will be two poster sessions and opportunities for junior scientists selected from the poster presenters to make oral presentations of their work within the main sessions. Each of the planned sessions will focus on timely and central aspects of calcium signaling, including the molecular nature and regulation of intracellular IP3 receptors, the spatial and temporal control of calcium signaling events, the role of mitochondria in calcium signaling and as mediators of cell injury and apoptosis, targets of calcium signaling in the brain and in peripheral tissues, and recent advances in the methodology for studying calcium and other intracellular ions. Participants include a combination of established and successful younger investigators representing an array of cellular systems and different techniques ranging from molecular biological analysis and manipulation of the calcium signaling machinery to sophisticated and pioneering micro- imaging technology to observe the generation and propagation of calcium signals. Basic disciplines of participants include biochemistry, physiology, cell biology, molecular biology, biophysics, pathology and pharmacology; however, all have a primary interest in understanding the mechanisms and significance of calcium signaling events in cells. The topics to be addressed at this meeting are important to our understanding of a number of health problems, including issues related to environmental health, cancer biology, cystic fibrosis, diabetes, neurodegenerative diseases and aging, to name a few.