MOLECULAR BIOLOGY OF NF1 AND NF2 MEETING

NF1 和 NF2 会议的分子生物学

• 批准号: 2884228
• 负责人: TYLER E. JACKS
• 金额: $ 3万
• 依托单位: CHILDREN'S TUMOR FOUNDATION
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-06-01 至 2000-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2884228
• 关键词: health science research; meeting /conference /symposium; molecular biology; molecular genetics; travel

Funding is requested to support the next meeting of the National Neurofibromatosis Foundation International Consortium for the Molecular Biology of NF1 and NF2 to be held June 20-22, 1999 at the Whitehead Institute in Cambridge, Massachusetts. Beginning in 1985, the NNFF Consortium meetings have served as the catalysts for many of the fundamental discoveries in the study of these important diseases of the nervous system. These meetings provide a regular forum to bring together basic researchers, geneticists, clinicians, and others familiar with NF1 and NF2 to share their latest research findings and experiences. NNFF Consortia have been instrumental in the rapid advances in the molecular understanding of NF1 and NF2, including the cloning of the responsible genes, establishment of diagnostic tests, exploration of gene function, development of animal models, and creation of infrastructure to establish a patient-clinician network to facilitate clinical trials. Following a recently established pattern, the 1999 Consortium meeting has been organized with a small format, which will be attended by invited speakers, session chairs and a small number of selected discussants. There will be five formal sessions, including an opening night keynote session. The four regular sessions will have 5 to 6 speakers each, including several junior investigators, and a session chair, who will provide an overview to the session and foster discussion. The speakers will be instructed to limit their presentations to approximately half of the allotted time, with the remainder dedicated to open discussion among all participants. The theme of the 1999 Consortium meeting is "NF1 and NF2: Defining Function," and the focus will be to explore the cell and molecular biological functions of these two genes through the use of biochemical, cell biological and in vivo approaches. This small format meeting, especially with the emphasis on open and active discussion, will maximize the chance for meaningful and potentially groundbreaking analysis of our current understanding of these issues. This meeting will also help to identify critical gaps in our knowledge and outline ideas, strategies and collaborations to address them. An improved understanding of the molecular basis of NF1 and NF2 has implication for disease pathogenesis, cancer biology generally, as well as a wide range of fundamental problems of cellular differentiation and development in the nervous system and beyond.

要求提供资金以支持将于1999年6月20日至22日在马萨诸塞州剑桥的怀特黑德研究所举行的国家神经纤维瘤病基金会NF 1和NF 2分子生物学国际联盟的下一次会议。 从1985年开始，NNFF联盟会议已经成为这些重要神经系统疾病研究中许多基本发现的催化剂。 这些会议提供了一个定期论坛，将基础研究人员，遗传学家，临床医生和其他熟悉NF 1和NF 2的人聚集在一起，分享他们的最新研究成果和经验。 NNFF联盟在NF 1和NF 2分子理解的快速发展中发挥了重要作用，包括克隆相关基因、建立诊断测试、探索基因功能、开发动物模型以及创建基础设施以建立患者-临床医生网络以促进临床试验。1999年联合会会议按照最近确定的模式，以小型形式组织，将由应邀发言者、会议主席和少数选定的讨论者出席。 将有五个正式会议，包括开幕之夜的主题会议。 四次常会将各有5至6名发言者，包括几名初级调查员和一名会议主席，他将概述会议并促进讨论。 将指示发言者将其发言时间限制在分配时间的一半左右，其余时间用于所有与会者之间的公开讨论。 一九九九年会议的主题为“NF 1及NF 2：定义功能”，重点是透过生物化学、细胞生物学及活体研究方法，探讨这两个基因的细胞及分子生物学功能。 这次小型会议，特别是强调公开和积极的讨论，将最大限度地提供机会，对我们目前对这些问题的理解进行有意义和可能具有开创性的分析。 这次会议还将有助于确定我们知识中的关键差距，并概述解决这些差距的想法、战略和合作。对NF 1和NF 2的分子基础的更好的理解对于疾病发病机制、癌症生物学以及神经系统和其他系统中细胞分化和发育的广泛的基本问题具有意义。