NEW BIOPOLYMERS DERIVED FROM ALPHA-L-AMINO ACIDS

源自 α-L-氨基酸的新型生物聚合物

• 批准号: 3072930
• 负责人: Joachim B. Kohn
• 金额: $ 6.91万
• 依托单位: RUTGERS, THE STATE UNIV OF N.J.
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-09-28 至 1995-09-27
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3072930
• 关键词: alanine; aminoacid; aminoacid analog; biomaterial development /preparation; chemical models; chemical synthesis; conformation; crosslink; laboratory mouse; ligands; nuclear magnetic resonance spectroscopy; peptide structure; polymerization; polymers; polyurethanes; racemization; serine; tyrosine

The candidate's long-term goal are to establish a laboratory with recognized expertise in biomaterials development, peptide chemistry and polymer chemistry. The candidate's work id focused on the design, synthesis and characterization of new molecular structures. In the areas of biomaterials research and polymer chemistry, the candidate is developing new methods for the modification of the backbone of synthetic poly(amino acids). His synthetic approach is based on the polymerization of alpha-L- amino acids via their side chains, resulting in the incorporation of non- amide bonds into the poly(amino acid) backbone. Such backbone-modified "pseudo-poly(amino acids) have potential uses as biomaterials for medical applications e.g. implantable devices, injectable drug carriers, and biocompatible coatings or membranes. The physical and chemical properties and the immunological and toxicological properties of pseudo-poly(amino acids) will be characterized. In the area of peptide chemistry, the candidate is exploring the possible use of urethane linkages as pseudopeptide mimetics of the conventional peptide bond. As a model system, a new cyclic pseudotetrapeptide has ben synthesized that contains two urethane bonds as part of its ring structure.

候选人的长期目标是建立一个实验室， 在生物材料开发、肽化学和 高分子化学 候选人的工作集中在设计上， 新分子结构的合成和表征。 领域的 生物材料研究和高分子化学，候选人正在开发 合成聚氨基甲酸酯主链改性的新方法 酸）。 他的合成方法是基于α-L- 氨基酸通过其侧链，导致非- 酰胺键结合到聚（氨基酸）主链中。 这种主链修饰 “假聚氨基酸具有作为医疗生物材料的潜在用途， 应用，例如可植入装置、可注射药物载体，以及 生物相容性涂层或膜。 理化性质 以及伪聚氨基甲酸酯的免疫学和毒理学性质 酸）将被表征。 在肽化学领域， 候选人正在探索氨基甲酸酯键的可能用途， 常规肽键的假肽模拟物。 为模特 合成了一种新环状假四肽， 两个氨基甲酸酯键作为其环结构的一部分。