ANIMAL RESOURCE FACILITY OF CHILES RESEARCH INSTITUTE

智利研究所动物资源设施

• 批准号: 3059107
• 负责人: R Kent HERMSMEYER
• 金额: $ 15.01万
• 依托单位: PROVIDENCE PORTLAND MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-08-01 至 1991-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3059107
• 关键词: animal care; animal colony; building /facility design /renovation

The Animal Resource Facility (ARF) at the Chiles Research Institute of Providence Medical Center consists of twelve rooms and associated entrance, hallways, and elevator in the basement floor near the loading dock of the hospital. This area has been converted from a gross human pathology laboratory to the facility for small animal (rodent) housing and care, with all cages of the individually ventilated type (Thoren), in two previous stages at the Chiles Research Institute. While much has been accomplished in these two previous stages with non-federal funds, the completion of this rodent facility requires the improvements described in this application as phase III. The goal of this animal facility improvement program will be to add improvements to complete the washroom, add cage racks, change stations, dumping station, bottle filler, microscope and blood pressure stations, and improve the ventilation required for the improved washroom. Although Providence Medical Center has allotted the space and provided previous substantial renovation, equipment, and support funds, adequate sanitation facilities and equipment, ventilation, and diagnostic equipment are still needed to achieve the goals of the improvement program. The 2,568 square foot rodent facility, enlarged by allocation of additional rooms, is divided into twelve rooms, including cleaning room, dump station, procedure room, toilet with shower, three animal housing rooms, and an office. All sections that are being renovated have sealed ceilings and walls, and seamless 'Tarkett' floors that are suitable for animal housing. The renovations requested consist of installation of a cage/bottle washer, adding doors and removing doors to improve traffic flow, conversion of the storage refrigerator to a dump station room, replacement of a locally fabricated hood with an approved fume hood, installation of a water bottle filler, and conversion of a toilet to an office. The equipment requested is for a cage/bottle washer, change and dump stations, additional racks of cages, blood pressure measurement system, and a microscope. Personnel to staff the ARF include Dr. Hermsmeyer, who will be the Director of the facility responsible to Dr. Gilbert and the Administration for its operation, Drs. Arthur Hall and Christine Parks, as veterinary consultants to the operation of the ARF and the Chiles Research Institute, and Patricia Weinrich, a certified laboratory animal technician (AALAS). We project that during the next year, 5,000-6,000 adult rats, 3,000-4,000 neonatal rats, and 3,000-4,000 mice from the ARF will be needed for experiments carried out as portions of funded NIH grants. The goals of this application are to improve cage cleaning, prevent cross-contamination, and provide a safe environment for caretakers and other staff.

智利研究所的动物资源设施（ARF） 普罗维登斯医疗中心由12个房间和相关入口组成， 走廊和电梯在地下室地板附近的装卸码头的 医院这个区域已经从一个严重的人类病理学 实验室到小动物（啮齿动物）饲养和护理设施， 所有单独通风类型的笼子（Thoren），在前两个 智利研究所的研究。 虽然在前两个阶段取得了很大成就， 非联邦资金，完成这个啮齿动物设施需要 在本申请中描述为阶段III的改进。这个目标 动物设施改善计划将增加改善完成 洗手间，增加笼架，更换站，倾倒站，瓶 填料，显微镜和血压站，并改善通风 需要改进的厕所。尽管普罗维登斯医疗中心 分配空间，并提供以前的大量装修，设备， 和支助资金，充足的卫生设施和设备， 仍然需要通风和诊断设备来实现这些目标 的改进方案。 2，568平方英尺的啮齿动物设施，通过分配额外的 房间，分为十二个房间，包括清洁室，垃圾站， 手术室、带淋浴的卫生间、三个动物饲养室和一个 办公室所有正在装修的部分都有密封的天花板， 墙壁和无缝的“Tarkett”地板，适合动物的住房。 要求进行的翻修包括安装一个笼式/洗瓶机， 增加和拆除车门以改善交通流量， 存储冰箱到转储站室，更换一个本地 装配式通风柜，配有经批准的通风柜，安装水瓶 填充物，以及将厕所转换为办公室。所要求的设备是 对于笼式/洗瓶机、更换和倾倒站， 笼子、血压测量系统和显微镜。 ARF的工作人员包括Hermsmeyer博士，他将担任主任 该机构对吉尔伯特博士和政府负责 手术，亚瑟霍尔和克莉丝汀公园博士，作为兽医顾问 对东盟地区论坛和智利研究所的运作，帕特里夏 Weinrich是一名经过认证的实验室动物技术员（AALAS）。 我们预计在接下来的一年里，5000 - 6000只成年大鼠，3000 - 4000只 新生大鼠和来自ARF的3，000 - 4，000只小鼠将用于 作为NIH赠款的一部分进行的实验。这个的目标 应用是为了改善笼清洁，防止交叉污染， 为管理员和其他工作人员提供安全的环境。