MATHEMATICAL MODELS OF INTERMEDIARY METABOLISM IN AGING
MATHEMATICAL MODELS OF INTERMEDIARY METABOLISM IN AGING
批准号:
3068455
负责人:
JOANNE Keene KELLEHER
金额:
$6.41万
依托单位国家:
美国
项目类别:
财政年份:
1988
资助国家:
美国
项目状态:
已结题
起止时间:
1988-05-01 至 1993-06-30
中文摘要
该SERCA提案的目标是提供机会,
数学建模领域的职业发展
衰老中的中间代谢。凯莱赫
候选人有十年以上的实验室工作经验
研究中间代谢和兴趣,
数学建模和老化。 候选人是NIA后-
博士研究员,并共同撰写了一篇论文,描述了
数学模型在老龄化研究领域的应用。
选择了两个建模研究领域,
在提案的最初几年进行研究。 1)“最小建模”是
一种选择最简洁模型的方法,
描述生理系统。 该过程可以
如果模型要在理解中有实际用途,
复杂的家庭系统。 2)"控制分析"是一种方法
用于分析代谢途径,取代"速率"的概念,
限制步骤”。 控制分析产生定量估计
在多大程度上通过整个途径的流量是
由每个反应控制。 虽然认识到建模
方法不是没有短句,本论文的建议
是将建模技术应用于
代谢稳态的老化将是非常有用的。
实验研究将集中在刺激
胰高血糖素在离体大鼠肝细胞中的促凋亡作用
成年(6个月)和老年(24个月)大鼠。 肝细胞的敏感性
将研究胰高血糖素。 长期目标是
候选人是把建模方法的专业知识,
研究人类衰老。
英文摘要
The goal of this SERCA proposal is to provide the opportunity for
career development in the area of mathematical modeling of
intermediary metabolism in aging for Dr. Joanne K. Kelleher.
The candidate has over ten years experience in laboratory
research in intermediary metabolism and an interest in
mathematical modeling and aging. The candidate was a NIA post-
doctoral fellow and has co-authored a paper describing the
application of mathematical models to the field of aging research.
Two areas of modeling research have been selected for detailed
study in the initial years of the proposal. 1) 'Minimal modeling' is
a method for selecting the most concise model capable of
describing the physiological system. This process may be
essential if models are to be of practical use in understanding
complex homoestated systems. 2) 'Control analysis' is a method
for analyzing metabolic pathways replacing the notion of "rate
limiting steps". Control analysis produces quantitative estimates
of the extent to which flux through the entire pathway is
controlled by each reaction. While it is recognized that modeling
methods are not without short comings, the thesis of this proposal
is that application of modeling techniques to the altered
metabolic homeostasis of aging will be extremely useful.
Experimental investigation will focus on the stimulation of
gluconeogenesis by glucagon in isolated rat hepatocytes from
adult (6 mo) and aged (24 mo) rats. The sensitivity of hepatocytes
to glucagon will be investigated. The long term goal of this
candidate is to bring expertise in modeling methodologies to the
study of human aging.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
ISOTOPOMER SPECTRAL ANALYSIS TO QUANTIFY BIOSYNTHESIS
-
批准号:3246715
-
项目类别:
-
资助金额:$28.42万
-
财政年份:1992
-
负责人:JOANNE Keene KELLEHER
-
依托单位:
ISOTOPOMER SPECTRAL ANALYSIS TO QUANTIFY BIOSYNTHESIS
-
批准号:3246714
-
项目类别:
-
资助金额:$27.21万
-
财政年份:1992
-
负责人:JOANNE Keene KELLEHER
-
依托单位:
ISOTOPOMER SPECTRAL ANALYSIS TO QUANTIFY BIOSYNTHESIS
-
批准号:2144387
-
项目类别:
-
资助金额:$31.96万
-
财政年份:1992
-
负责人:JOANNE Keene KELLEHER
-
依托单位:
ISOTOPOMER SPECTRAL ANALYSIS TO QUANTIFY BIOSYNTHESIS
-
批准号:2144388
-
项目类别:
-
资助金额:$33.26万
-
财政年份:1992
-
负责人:JOANNE Keene KELLEHER
-
依托单位:
ISOTOPOMER SPECTRAL ANALYSIS TO QUANTIFY BIOSYNTHESIS
-
批准号:2144386
-
项目类别:
-
资助金额:$30.54万
-
财政年份:1992
-
负责人:JOANNE Keene KELLEHER
-
依托单位:
MATHEMATICAL MODELS OF INTERMEDIARY METABOLISM IN AGING
-
批准号:3068456
-
项目类别:
-
资助金额:$8.88万
-
财政年份:1988
-
负责人:JOANNE Keene KELLEHER
-
依托单位:
MATHEMATICAL MODELS OF INTERMEDIARY METABOLISM IN AGING
-
批准号:3068454
-
项目类别:
-
资助金额:$6.44万
-
财政年份:1988
-
负责人:JOANNE Keene KELLEHER
-
依托单位:
MATHEMATICAL MODELS OF INTERMEDIARY METABOLISM IN AGING
-
批准号:3068457
-
项目类别:
-
资助金额:$8.89万
-
财政年份:1988
-
负责人:JOANNE Keene KELLEHER
-
依托单位:
MATHEMATICAL MODELS OF INTERMEDIARY METABOLISM IN AGING
-
批准号:3068453
-
项目类别:
-
资助金额:$6.22万
-
财政年份:1988
-
负责人:JOANNE Keene KELLEHER
-
依托单位:
IMPROVED GLUCONEOGENESIS ESTIMATES FROM LABELED CARBON
-
批准号:3236623
-
项目类别:
-
资助金额:$4.24万
-
财政年份:1986
-
负责人:JOANNE Keene KELLEHER
-
依托单位:
IMPROVED GLUCONEOGENESIS ESTIMATES FROM LABELED CARBON
-
批准号:3236621
-
项目类别:
-
资助金额:$9.35万
-
财政年份:1986
-
负责人:JOANNE Keene KELLEHER
-
依托单位:
IMPROVED GLUCONEOGENESIS ESTIMATES FROM LABELED CARBON
-
批准号:3236622
-
项目类别:
-
资助金额:$9.41万
-
财政年份:1986
-
负责人:JOANNE Keene KELLEHER
-
依托单位:
METABOLIC FLUX PATTERNS IN HEPATOMA CELLS
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批准号:3283399
-
项目类别:
-
资助金额:$11.83万
-
财政年份:1985
-
负责人:JOANNE Keene KELLEHER
-
依托单位:
METABOLIC FLUX PATTERNS IN HEPATOMA CELLS
-
批准号:3283401
-
项目类别:
-
资助金额:$12.4万
-
财政年份:1985
-
负责人:JOANNE Keene KELLEHER
-
依托单位:
METABOLIC FLUX PATTERNS IN HEPATOMA CELLS
-
批准号:3283395
-
项目类别:
-
资助金额:$12.61万
-
财政年份:1985
-
负责人:JOANNE Keene KELLEHER
-
依托单位:
METABOLIC FLUX PATTERNS IN HEPATOMA CELLS
-
批准号:3283400
-
项目类别:
-
资助金额:$12.52万
-
财政年份:1985
-
负责人:JOANNE Keene KELLEHER
-
依托单位:
METABOLIC FLUX PATTERNS IN HEPATOMA CELLS
-
批准号:3283398
-
项目类别:
-
资助金额:$10.33万
-
财政年份:1985
-
负责人:JOANNE Keene KELLEHER
-
依托单位:
METABOLIC FLUX PATTERNS IN HEPATOMA AND HEPATOCYTES
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批准号:3283396
-
项目类别:
-
资助金额:$7.96万
-
财政年份:1985
-
负责人:JOANNE Keene KELLEHER
-
依托单位:
METABOLIC FLUX PATTERNS IN HEPATOMA AND HEPATOCYTES
-
批准号:3283397
-
项目类别:
-
资助金额:$9.56万
-
财政年份:1985
-
负责人:JOANNE Keene KELLEHER
-
依托单位:
METABOLIC FLUX PATTERNS IN HEPATOMA AND HEPATOCYTES
-
批准号:3283393
-
项目类别:
-
资助金额:$9.73万
-
财政年份:1985
-
负责人:JOANNE Keene KELLEHER
-
依托单位: