Identifying parent-of-origin effects and their impact on complex traits

识别亲本效应及其对复杂性状的影响

• 批准号: DE180100976
• 负责人: Dr Gabriel Cuellar Partida
• 金额: $ 13.01万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-03-31 至 2020-02-06
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE180100976
• 关键词: Identifying; parent; origin; effects; their

This project aims to systematically identify genetic variants whose effects depend on whether they were inherited from the mother or the father, and to assess their impact on complex human traits. Most gene mapping studies to date assume that the effects of genetic variants are equal regardless of the parent of origin, thus have not explored this source of genetic variation. However, animal studies indicate that parent-of-origin specific effects (POEs) are important contributors to variability of developmental and behavioural traits. Leveraging genetic and epigenetic data from some of the world’s largest cohorts, this project will improve our understanding of POEs on complex human traits related to early development, growth and behaviour.

该项目旨在系统地识别遗传变异，其影响取决于它们是从母亲还是父亲遗传的，并评估它们对复杂人类特征的影响。迄今为止，大多数基因图谱研究都假设遗传变异的影响是相同的，无论其来源如何，因此尚未探索遗传变异的这种来源。然而，动物研究表明，亲本特异性效应（POE）是导致发育和行为特征变异的重要因素。该项目利用来自世界上一些最大群体的遗传和表观遗传数据，将提高我们对与早期发育、生长和行为相关的复杂人类特征的 POE 的理解。