Identifying parent-of-origin effects and their impact on complex traits

该项目旨在系统地识别遗传变异，其影响取决于它们是从母亲还是父亲遗传的，并评估它们对复杂人类特征的影响。迄今为止，大多数基因图谱研究都假设无论起源于哪种亲本，遗传变异的影响都是相等的，因此尚未探索遗传变异的这种来源。然而，动物研究表明，父母的原产地特定的影响（POE）是重要的贡献者的发展和行为特征的变异。利用来自世界上一些最大群体的遗传和表观遗传数据，该项目将提高我们对与早期发育，生长和行为相关的复杂人类特征的POE的理解。

This project aims to systematically identify genetic variants whose effects depend on whether they were inherited from the mother or the father, and to assess their impact on complex human traits. Most gene mapping studies to date assume that the effects of genetic variants are equal regardless of the parent of origin, thus have not explored this source of genetic variation. However, animal studies indicate that parent-of-origin specific effects (POEs) are important contributors to variability of developmental and behavioural traits. Leveraging genetic and epigenetic data from some of the world’s largest cohorts, this project will improve our understanding of POEs on complex human traits related to early development, growth and behaviour.