Stronger together: understanding antibiotic synergy on a molecular level

强强联手：从分子水平了解抗生素的协同作用

• 批准号: DE180100929
• 负责人: A/Prof Amy Cain
• 金额: $ 25.55万
• 依托单位: Macquarie University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-12-03 至 2022-12-03
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE180100929
• 关键词: Stronger; together; understanding; antibiotic; synergy

This project aims to use genomics-based approaches to answer fundamental questions about how antibiotic synergy works. Antibiotic combination therapy presents an opportunity to revive the use of antibiotics in otherwise resistant bacteria, yet currently there is little understanding of the molecular mechanisms underlying antibiotic synergy. Studies indicate that additional mechanisms of action (MOA) occur during synergistic killing beyond those of the original antibiotics. This project will identify genes involved in multiple synergistic treatments and determine how bacterial cells gain resistance. The synergy-specific MOA identified also represent an untapped reservoir of primary drug targets.

该项目旨在使用基于基因组学的方法来回答有关抗生素协同作用如何起作用的基本问题。抗生素联合治疗为恢复抗生素在耐药细菌中的使用提供了机会，但目前对抗生素协同作用的分子机制知之甚少。研究表明，在协同杀伤过程中，除了原始抗生素之外，还存在其他作用机制（MOA）。该项目将确定参与多种协同治疗的基因，并确定细菌细胞如何获得耐药性。所确定的协同特异性MOA也代表了尚未开发的主要药物靶点库。