GABAERGIC ADAPTATION IN ETHANOL TOLERANCE & DEPENDENCE

本提案要求ADAMHA RSDA二级支持 关于Gerald D Frye博士与R 01 AA 06322密切相关， 弗莱医生是私家侦探 这个奖项将使弗莱博士的 大学和部门服务的职责， 这样他就可以在学校里学习了。 90%的时间用于研究和专业发展。 那些 Frye博士的研究不再需要的部门资源 支持将用于招聘额外的教员， 与酒精和药物滥用有关的生物化学研究兴趣 问题. 弗莱博士的研究工作将继续集中在 GABAA和GABAB受体/转导子复合物作用 在酒精中毒、耐受性和身体机能的发生中起作用 依赖 正在测试的假设是，“急性或 乙醇的慢性作用部分取决于增加或 GABA受体的功效降低，分别作为突触 传感器”。 研究的目的是评估 乙醇处理对模型GABAA和GABAB生理的影响 受体系统 弗莱博士不仅会继续他的研究 使用豚鼠回肠，但他将扩大他的研究 通过学习新的神经生理学技术进行训练 海马切片通过一个重要的合作与博士。 威廉·格里菲斯 增加培训机会， 研究应来自其他计划的合作领域 其中GABA受体-乙醇相互作用可能是 乙醇中毒的根本原因。 在这方面，初步 与Kelly Hester博士合作（心血管生理学 Jack Nations博士（重金属毒性和高血压） （1）个人的选择，以及个人的选择。 离子通道生物化学系。 这些新的计划 培训和加强跨学科研究合作 会大大提高弗莱博士的专业发展 作为一名基础科学家， 乙醇

This proposal is a request for an ADAMHA RSDA level II support for Gerald D. Frye, Ph.D. and closely related to R01 AA06322 on which Dr. Frye is the PI. This award will allow Dr. Frye's responsibilities for University and Department service and teaching to be reduced so that he will be able to apply at least 90% of his time to research and professional development. Those departmental resources that are no longer required for Dr. Frye's support will be used to recruit an additional faculty member with biochemical research interests related to alcohol and drug abuse questions. Dr. Frye's research efforts will continue to focus on the role that GABAA and GABAB receptor/transducer complexes play in the genesis of ethanol intoxication, tolerance and physical dependence. The hypothesis being tested is that, "acute or chronic actions of ethanol depend in part on increased or decreased efficacy of GABA receptors, respectively, as synaptic transducers". Studies are designed to evaluate the influence of ethanol treatment on the physiology of model GABAA and GABAB receptor systems. Not only will Dr. Frye continue his research using the guinea pig ileum but he will broaden his research training by learning new neurophysiological techniques in the rat hippocampal slice through an important collaboration with Dr. William Griffith. Additional opportunities for training and new research should come form other planned collaborations in areas where a GABA receptor-ethanol interaction could be an underlying cause of ethanol toxicity. In this regard preliminary collaborations with Dr. Kelly Hester (cardiovascular physiology and hypertension); Dr. Jack Nations (heavy metals toxicity and ethanol preference); and and individual yet to be hired by the Department (ion channel biochemistry). These plans for new training and increased interdisciplinary research collaboration should significantly enhance Dr. Frye's professional development as a basic scientist interested in the biomedical impact of ethanol.