DYNAMICS OF RESPIRATORY INSTABILITY IN HUMANS IN SLEEP

本次申请研究职业发展奖的目的是 允许首席调查员(PI)投入大得多的 他花了一部分时间来研究睡眠对控制组的影响 呼吸的感觉。在本提议项目的任期内，国际和平研究所将 将数学建模和参数估计方法与 在人体上进行实验，以更好地了解这种动态 导致呼吸变异性和反复呼吸暂停的机制 睡吧。区域发展管理局将腾出足够的时间让他进行 建议的研究，以及在临床和 通过阅读增加互动对睡眠的神经生理学影响 与该领域的专家进行交流，并参加座谈会。这个 通过这种机会获得的经验和培训将是 对于他现在和未来的发展来说是无价的，因为独立的 睡眠生理学研究人员，尤其是与 呼吸控制。同时，PI将能够探索 从非线性动力学、混沌派生的新方法的适用性 理论和神经网络。在大学里出现了几个人 这些新领域的专家以及神经科学的专家提供了一种 理想的学术成长环境。包括两个 临床同事，一个在肺内科，另一个在睡眠 障碍，因为该项目的合作调查员将显著改善 PI对睡眠的病理生理学方面的欣赏。 在拟议的项目中，将在两个健康的 受试者与睡眠呼吸暂停综合征患者的亲缘关系 化学反应的重要性，动脉血气的敏感性 对通风变化(植物增益)、呼吸相转换、 睡眠状态改变与上呼吸道力学在调节睡眠相关中的作用 呼吸障碍。简单的非侵入性手术结合特殊的 设计的计算算法将允许跟踪 睡眠期间的化学反应、植物生长和动脉血气。 模型的应用也允许估计时间进程 “觉醒刺激”。分析了时间关系之间的关系 这些因素和上呼吸道阻力的变化将被用来延长 睡眠状态与呼吸之间相互作用的现有模型 控制力。

The purpose of this application for a Research Career Development Award is to permit the Principal Investigator (PI) to devote a substantially greater portion of his time for research into the effects of sleep on the control of breathing. During the tenure of this proposes project, the PI will combine mathematical modeling and parameter estimation methodology with experiments on humans to obtain a better understanding of the dynamic mechanisms that lead to respiratory variability and recurrent apnea during sleep. The RCDA will free up sufficient time for him to conduct the proposed studies, as well as to obtain a firm grounding in the clinical and neurophysiological aspects of sleep through reading, increased interactions with experts in the field, and participation in colloquiums. The experience and training obtained through such an opportunity would be invaluable for his current and future development as in independent investigator in sleep physiology, particularly as it pertains to respiratory control. At the same time, the PI will be able to explore the applicability of new approaches derived from nonlinear dynamics, chaos theory and neural networks. The presence within the University of several experts in these new areas, as well as in the neurosciences, provides an ideal environment for the academic growth of the PI. The inclusion of two clinical colleagues, one in pulmonary medicine and the other in sleep disorders, as Co-Investigators in this project will significantly improve the PI's appreciation of the pathophysiological aspects of sleep. In the proposed project, experiments will be performed on both healthy subjects and patients with sleep apnea syndrome to determine the relative importance of chemoresponsiveness, sensitivity of arterial blood gas tensions to ventilatory changes (plant gain), respiratory phase-switching, sleep state changes and upper airway mechanics in mediating sleep-related breathing disorders. Simple noninvasive procedures combined with specially designed computational algorithms will be permit the tracking of chemoresponsiveness, plant gain, and arterial blood gases during sleep. Application of modeling also allows the estimation of the time-course for the 'wakefulness stimulus'. Analysis of the temporal relationships between these factors and changes in upper airway resistance will be used to extend an existing model of the interaction between sleep state and respiratory control.