REFLEX CONTROL MECHANISMS OF GASTROINTESTINAL SPHINCTERS

胃肠括约肌的反射控制机制

• 批准号: 3079001
• 负责人: JAMES C REYNOLDS
• 金额: $ 7.77万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1983
• 资助国家: 美国
• 起止时间: 1983-08-01 至 1986-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3079001
• 关键词: autonomic reflex; duodenum; electrodes; electromyography; esophagogastric junction; esophagus motility /pressure; gastrointestinal function; gastrointestinal pharmacology; membrane potentials; neurotransmitters; pyloric region; triglycerides; tryptophan

The lower esophageal sphincter (LES) and pylorus play important roles in controlling the transit of substances from the stomach. Numerous hormones, peptides and neurotransmitters have been shown to have an effect on these sphincters. The specific agents and mechanisms which control sphincter reflexes in vivo remain ill defined. Myoelectric recordings have been used to define the mechanisms of motor function in many areas but only limited studies on the myoelectric correlates of LES and pyloric function are available. These studies will evaluate the mechanisms through which the LES and pylorus respond to intrinsic reflexes. First, we will quantitate the myoelectric correlates of sphincter function. Specifically these studies will clarify the significance of spike discharges in the recording of phasic and tonic sphincteric contractions. Second, to determine how the underlying myoelectric properties of these sphincters control the way in which the sphincter responds to stimuli. Third, to determine the location and specificity of receptors that initiate the reflex control of spincter tone. Fourth, to determine the specific transmitter agents and pathways involved in these reflexes. It is anticipated that the identification of factors which act to regulate sphincter function will lead to an increased understanding of the disease mechanisms that effect these sphincters.

食管下端括约肌 (LES) 和幽门在食管癌中发挥着重要作用。 控制物质从胃中的转运。 多种荷尔蒙， 肽和神经递质已被证明对这些有影响 括约肌。 控制括约肌的具体药物和机制 体内反射仍然不明确。 已使用肌电记录 定义许多领域但有限的运动功能机制 LES 与幽门功能的肌电相关性研究 可用的。 这些研究将评估以下机制： LES 和幽门对内在反射做出反应。 首先，我们要量化 括约肌功能的肌电相关性。 具体来说这些 研究将阐明记录中尖峰放电的重要性 括约肌的阶段性和强直性收缩。 其次，确定如何 这些括约肌的潜在肌电特性控制着 括约肌对刺激做出反应。 三、确定位置 以及启动括约肌反射控制的受体的特异性 语气。 四、确定具体的递质及途径 参与这些反射。 预计鉴定 调节括约肌功能的因素会导致增加 了解影响这些括约肌的疾病机制。

项目成果

Opiate nerves mediate feline pyloric response to intraduodenal amino acids.

阿片神经介导猫幽门对十二指肠内氨基酸的反应。

• DOI: 10.1152/ajpgi.1985.248.3.g307
• 发表时间: 1985
• 期刊: The American journal of physiology
• 作者: Reynolds,JC;Ouyang,A;Cohen,S
• 通讯作者: Cohen,S