PERIPHERAL MECHANISMS OF ESOPHAGEAL PERISTALSIS

本建议的总体目标是详细审查 负责蠕动行为的壁内机制 食道的平滑肌部分。 具体而言，这将 涉及使用电生理细胞内记录 技术来检查肌壁间的突触传递 在食管中的肌间神经丛的神经以及在 神经肌肉部位。 这些研究的结果应该提供一个 增加了对肌壁内神经肌肉 机制参与食管糜烂，并导致更好的 了解此类疾病的病理生理学和管理 食管疾病，如贲门失弛缓症和弥漫性食管痉挛。 博士克里斯特目前是英国医学院的医学讲师 贝斯以色列医院和哈佛的胃肠病学分部 医学院 在Raj K.戈亚尔，他 获得了一项个人国家研究服务 奖（1983-1985）和临床研究者奖（1985-1988） 来研究食管癌的发病机制 候选人在此期间的研究导致 6篇原创文章（见附录）。 通过临床研究者奖博士提供的资金。 克里斯特最近在R.A.博士的实验室工作。 North和A.马萨诸塞州研究所的Surprenant 技术. 这段经历让克里斯特医生成为 熟悉电生理技术， 目前的提案。 赞助商Raj K博士戈亚尔，医学教授， 哈佛医学院和贝斯消化科主任 以色列医院，是该领域公认的领导者， 胃肠蠕动 戈亚尔博士的赞助，以及 贝丝以色列医院和哈佛的调查人员 医学院，应该提供一个良好的环境， 候选人的研究和全面发展，成为一个 独立调查员

The overall objective of this proposal is to examine in detail the intramural mechanisms responsible for peristaltic behavior in the smooth muscle portion of the esophagus. Specifically, this will involve the use of electrophysiological intracellular recording techniques to examine synaptic transmission between intramural nerves of the myenteric plexus in the esophagus as well as at the neuromuscular site. The results of these studies should provide an increased understanding of the intramural neuromuscular mechanisms involved in esophageal peristalsis and lead to a better understanding of the pathophysiology and management of such esophageal disorders as achalasia and diffuse esophageal spasm. Dr. Crist is presently an Instructor in Medicine in the Gastroenterology Division of the Beth Israel Hospital and Harvard Medical School. Under the sponsorship of Dr. Raj K. Goyal, he has been the recipient of an Individual National Research Service Award (1983-1985) and a Clinical Investigator Award (1985-1988) to study the mechanisms responsible for esophageal peristalsis. Studies by the candidate during this time period have resulted in six original publications (see Appendix). Through funding provided by the Clinical Investigator Award Dr. Crist has most recently worked in the laboratory of Drs. R.A. North and A. Surprenant at Massachusetts Institute of Technology. This experience has allowed Dr. Crist to become knowledgeable in the electrophysiological techniques to be used in the present proposal. The sponsor, Dr. Raj K. Goyal, is Professor of Medicine at Harvard Medical School and Chief of Gastroenterology at Beth Israel Hospital and is an acknowledged leader in the area of gastrointestinal motility. Dr. Goyal's sponsorship, as well as the surrounding investigators at Beth Israel Hospital and Harvard Medical School, should provide an excellent environment for the candidate's studies and overall development toward becoming an independent investigator.