NHLBI CLINICAL INVESTIGATOR AWARD PROGRAM

这一奖项旨在进一步发展一名 个人的长期职业目标是成为一个独立的人 年与容量动态平衡和高血压相关的领域的研究人员 怀孕了。实验，旨在阐明水的处理和作用 在正常和异常妊娠期间，加压素(AVP)的含量将是 在M.D.林德海默博士的赞助下进行如下：I. 水代谢：导致妊娠减少的因素 血浆渗透压(POSM)与AVP分泌阈值和饮酒阈值 将会被调查。将检查连续的血压和POSM 以确定在整个怀孕期间是否平均妊娠减少 动脉压可能是渗透调节改变的原因 同时将对假孕大鼠进行研究，以确定胎儿胎盘 在这些变化中，单位扮演着特定的角色。有没有可能 肾素-血管紧张素系统、催乳素和内啡肽也将参与其中 通过给处女动物和/或 通过抑制怀孕动物体内的特定激素。二、 高血压：这些研究的目的是研究血管加压素和 妊娠期血压控制的相关激素系统 在(1)血压正常的Wistar-京都大鼠，(2)人类的动物模型 原发性高血压，即自发性高血压大鼠，以及(3)AN 人先兆子痫动物(大鼠)模型。将进行实验，以 血管对血管加压素、血管紧张素Ⅱ和儿茶酚胺反应性的测定 此外，每个人在维持血液方面的贡献 压力将通过对特定血管的管理进行评估 封闭剂。在平行实验中，血压、体积和水平 上述激素的含量将在妊娠早期、中期和晚期进行测量。 在人体研究中，水处理，AVP分泌，血浆肾素活性和 儿茶酚胺将在血压正常的妇女和孕妇中进行比较 轻度高血压使用生理刺激，如水负荷和 限制。容量动态平衡、水处理和血压控制 人们对怀孕期间的情况知之甚少。从当前获取的信息 调查将有助于更好地了解这些现象 并可能导致高血压临床管理的改进 使妊娠复杂化的疾病。

This award is sought to further develop the research skills of an individual whose long-term career goal is to become an independent investigator in areas related to volume homeostasis and hypertension in pregnancy. Experiments, designed to elucidate water handling and the role of vasopressin (AVP) during both normal and abnormal gestation will be performed under the sponsorship of Dr. M.D. Lindheimer as follows: I. Water Metabolism: The factors responsible for gestational decreases in both plasma osmolality (Posm) and thresholds for AVP secretion and drinking will be investigated. Serial blood pressure and Posm will be examined throughout pregnancy to determine whether the gestational decrement in mean arterial pressure may be responsible for alterations in osmoregulation while pseudopregnant rats will be studied to determine if the fetoplacental unit plays a specific role in these changes. The possibility that the renin-angiotensin system, prolactin and endorphins are involved will also be examined through administration of hormone to virgin animals and/or through inhibition of specific hormones in gravid animals. II. Hypertension: These studies aim to investigate the role of vasopressin and related hormonal systems in the control of blood pressure during pregnancy in (1) normotensive Wistar-Kyoto rats, (2) an animal model of human essential hypertension, i.e. the spontaneously hypertensive rat, and (3) an animal (rat) model of human preeclampsia. Experiments will be performed to determine the vascular reactivity to AVP, angiotensin II and catecholamines and in addition the contribution of each in the maintenance of blood pressure will be assessed through the administration of specific vascular blocking agents. In parallel experiments blood pressure, volume and levels of the above hormones will be measured in early, mid and late gestation. In human studies water handling, AVP secretion, plasma renin activity and catecholamines will be compared in normotensive women and in gravidas with mild hypertension using physiological stimuli such as water loading and restriction. Volume homeostasis, water handling and blood pressure control in pregnancy are poorly understood. Information gained from present investigations will contribute to a better understanding of these phenomena and may lead to improvement in the clinical management of hypertensive disorders complicating gestation.