PROSTAGLANDIN REGULATION IN VASCULAR ENDOTHELIUM

血管内皮中前列腺素的调节

• 批准号: 3083383
• 负责人: DAVID P CARLTON
• 金额: $ 8.35万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-07-01 至 1998-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3083383
• 关键词: arachidonate; aspirin; dexamethasone; eicosanoid metabolism; enzyme activity; gas chromatography mass spectrometry; human tissue; low density lipoprotein; messenger RNA; northern blottings; phospholipase A2; phospholipase C; prostaglandin endoperoxide synthase; prostaglandins; thin layer chromatography; tissue /cell culture; tumor necrosis factor alpha; vascular endothelium; western blottings

The vascular endothelium is important in maintaining hemostasis and vascular tone. Because of its unique location, it is readily exposed to circulating mediators, many of which influence fundamental cellular processes. Tumor necrosis factor is one of the inflammatory mediators that critically affects endothelial cell function. This proposal, entitled Prostaglandin Regulation in Vascular Endothelium, will explore an important aspect of endothelial cell physiology disrupted by tumor necrosis factor: the regulation of prostaglandin synthesis. This project will specifically examine the mechanism whereby tumor necrosis factor increases prostaglandin metabolism in endothelial cells. Tumor necrosis factor and prostaglandins play a role in a number of human conditions.

血管内皮对于维持止血和维持功能很重要 血管张力。 由于其独特的地理位置，很容易接触到 循环介质，其中许多影响基本细胞 流程。 肿瘤坏死因子是炎症介质之一 严重影响内皮细胞功能。 该提案题为“血管内皮中的前列腺素调节”， 将探索内皮细胞生理学被破坏的一个重要方面 受肿瘤坏死因子：前列腺素合成的调节。 该项目将专门研究肿瘤的机制 坏死因子增加内皮细胞中前列腺素的代谢。 肿瘤坏死因子和前列腺素在人类许多细胞中发挥作用 状况。