VIRUS-CELL INTERACTION AND INITIATION OF INFECTION

这项培训计划的目标有两个。首先， 申请人，曾接受过广泛的内科和 传染病，希望投入大量的时间和精力 基础研究培训，使他能够建立一个 病毒分子方面的独立研究计划 发病机制。计划的培训计划包括一套 病毒学和遗传学毕业生的典型课程 学生；研究会议、期刊俱乐部和研讨会；以及 旨在提供战略培训的研究计划 以及病毒学、分子生物学、遗传学和细胞学技术 生物学。第二，申请人希望实现某些目标 计划的研究计划中的目标。这些都是为了定义 单纯疱疹病毒重要糖蛋白之一的作用 病毒粒子形态发生，病毒粒子吸附到细胞，病毒 穿透细胞和病毒诱导的细胞融合(第一阶段)。在……里面 第二阶段，目标将是确定和描述 这种糖蛋白与之相互作用的细胞表面成分。 这项工作的长期目标是增加我们对 单纯疱疹病毒感染的发病机制和 制定其预防和治疗策略。

The objective of this training program are two-fold. First, the applicant, who has had extensive training in internal medicine and infectious diseases, wishes to devote significant time and effort to basic research training to enable him to establish an independent research program on molecular aspects of viral pathogenesis. The training program planned includes a set of courses typical of those taken by Virology and Genetics graduate students; research meetings, journal clubs and seminars; and a research program designed to provide training in the strategies and technology of virology, molecular biology, genetics and cell biology. Second, the applicant wishes to accomplish certain objectives in the research program planned. These are to define the roles of one of the essential glycoproteins of herpes simplex virus in virion morphogenesis, virion adsorption to cells, viral penetration into cells and virus-induced cell fusion (phase I). In phase II, the objectives will be to identify and characterize the cell surface components with which this glycoprotein interacts. The long term goals of this work are to increase our understanding of the pathogenesis of herpes simplex virus infections and to develop strategies for its prevention and treatment.